Long-term follow-up of cutaneous hypersensitivity in rats with a spinal cord contusion

Ji In Jung, Junesun Kim, Seung Kil Hong, Young Wook Yoon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalKorean Journal of Physiology and Pharmacology
Volume12
Issue number6
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Spinal Cord Injuries
Hypersensitivity
Skin
Hyperalgesia
Contusions
Neuralgia
Acetone
Pain
Wounds and Injuries
Chronic Pain
Analgesics
Animal Models
Observation
Weights and Measures
Research

Keywords

  • Central neuropathic pain
  • Cold allodynia
  • Mechanical allodynia
  • Spinal cord contusion
  • Spinal cord injury

ASJC Scopus subject areas

  • Pharmacology
  • Physiology

Cite this

Long-term follow-up of cutaneous hypersensitivity in rats with a spinal cord contusion. / Jung, Ji In; Kim, Junesun; Hong, Seung Kil; Yoon, Young Wook.

In: Korean Journal of Physiology and Pharmacology, Vol. 12, No. 6, 01.12.2008, p. 299-306.

Research output: Contribution to journalArticle

@article{8d6880d8ec5f49e6b2c4754ae4adc466,
title = "Long-term follow-up of cutaneous hypersensitivity in rats with a spinal cord contusion",
abstract = "Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.",
keywords = "Central neuropathic pain, Cold allodynia, Mechanical allodynia, Spinal cord contusion, Spinal cord injury",
author = "Jung, {Ji In} and Junesun Kim and Hong, {Seung Kil} and Yoon, {Young Wook}",
year = "2008",
month = "12",
day = "1",
doi = "10.4196/kjpp.2008.12.6.299",
language = "English",
volume = "12",
pages = "299--306",
journal = "Korean Journal of Physiology and Pharmacology",
issn = "1226-4512",
publisher = "Korean Physiological Soc. and Korean Soc. of Pharmacology",
number = "6",

}

TY - JOUR

T1 - Long-term follow-up of cutaneous hypersensitivity in rats with a spinal cord contusion

AU - Jung, Ji In

AU - Kim, Junesun

AU - Hong, Seung Kil

AU - Yoon, Young Wook

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.

AB - Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.

KW - Central neuropathic pain

KW - Cold allodynia

KW - Mechanical allodynia

KW - Spinal cord contusion

KW - Spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=58249102998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58249102998&partnerID=8YFLogxK

U2 - 10.4196/kjpp.2008.12.6.299

DO - 10.4196/kjpp.2008.12.6.299

M3 - Article

C2 - 19967071

AN - SCOPUS:58249102998

VL - 12

SP - 299

EP - 306

JO - Korean Journal of Physiology and Pharmacology

JF - Korean Journal of Physiology and Pharmacology

SN - 1226-4512

IS - 6

ER -