Long-term immunogenicity of influenza vaccine among the elderly

Risk factors for poor immune response and persistence

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.

Original languageEnglish
Pages (from-to)3929-3935
Number of pages7
JournalVaccine
Volume28
Issue number23
DOIs
Publication statusPublished - 2010 May 21

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Influenza Vaccines
influenza
Vaccination
risk factors
vaccination
immune response
vaccines
Hemagglutinins
hemagglutinins
Accidental Falls
young adults
Human Influenza
Young Adult
Age Groups
viruses
antibodies
Antibodies
Serum

Keywords

  • Elderly
  • Immunogenicity
  • Influenza
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Long-term immunogenicity of influenza vaccine among the elderly : Risk factors for poor immune response and persistence. / Song, Joon-Young; Cheong, Hee-Jin; Hwang, In Sook; Choi, Wonseok; Jo, Yu Mi; Park, Dae Won; Cho, Geum-Joon; Hwang, Taik Gun; Kim, Woo Joo.

In: Vaccine, Vol. 28, No. 23, 21.05.2010, p. 3929-3935.

Research output: Contribution to journalArticle

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