Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence

Joon Young Song, Hee Jin Cheong, In Sook Hwang, Won Suk Choi, Yu Mi Jo, Dae Won Park, Geum Joo Cho, Taik Gun Hwang, Woo Joo Kim

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.

Original languageEnglish
Pages (from-to)3929-3935
Number of pages7
JournalVaccine
Volume28
Issue number23
DOIs
Publication statusPublished - 2010 May 21

Keywords

  • Elderly
  • Immunogenicity
  • Influenza
  • Vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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