Abstract
The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.
| Original language | English |
|---|---|
| Pages (from-to) | 3929-3935 |
| Number of pages | 7 |
| Journal | Vaccine |
| Volume | 28 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2010 May 21 |
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Keywords
- Elderly
- Immunogenicity
- Influenza
- Vaccination
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
- Molecular Medicine
Cite this
Long-term immunogenicity of influenza vaccine among the elderly : Risk factors for poor immune response and persistence. / Song, Joon-Young; Cheong, Hee-Jin; Hwang, In Sook; Choi, Wonseok; Jo, Yu Mi; Park, Dae Won; Cho, Geum-Joon; Hwang, Taik Gun; Kim, Woo Joo.
In: Vaccine, Vol. 28, No. 23, 21.05.2010, p. 3929-3935.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term immunogenicity of influenza vaccine among the elderly
T2 - Risk factors for poor immune response and persistence
AU - Song, Joon-Young
AU - Cheong, Hee-Jin
AU - Hwang, In Sook
AU - Choi, Wonseok
AU - Jo, Yu Mi
AU - Park, Dae Won
AU - Cho, Geum-Joon
AU - Hwang, Taik Gun
AU - Kim, Woo Joo
PY - 2010/5/21
Y1 - 2010/5/21
N2 - The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.
AB - The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination.
KW - Elderly
KW - Immunogenicity
KW - Influenza
KW - Vaccination
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U2 - 10.1016/j.vaccine.2010.03.067
DO - 10.1016/j.vaccine.2010.03.067
M3 - Article
VL - 28
SP - 3929
EP - 3935
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 23
ER -