Long-term oral administration of ginseng extract decreases serum gamma-globulin and IgG1 isotype in mice

Y. W. Kim, D. K. Song, W. H. Kim, K. M. Lee, M. B. Wie, Y. H. Kim, Sun-Ho Kee, M. K. Cho

Research output: Contribution to journalArticle

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Abstract

Effects of long-term oral administration of ginseng extract on serum protein profile and immunoglobulin (Ig) isotypes were studied in mice. Ginseng extract was orally administered to healthy female mice for 52 days at doses of 30 and 150 mg/kg per day and serum protein electrophoretograms and Ig isotypes levels were evaluated. Serum level of γ-globulin was decreased dose dependently to 82% (P < 0.05) and 56% (P < 0.01) of control values at the doses of 30 and 150 mg/kg per day, respectively. Levels of total protein, albumin, α2- and β-globulin fractions, as well as the ratio of albumin to globulin (A/G) did not change significantly. However, the α1-globulin level increased by 24% (P < 0.05) at the doses of 30 and 150 mg/kg per day. Among the Ig isotypes, including IgG1, IgG(2a), IgG(2b), IgG3, IgM and IgA, serum IgG1 was dose dependently decreased to 68% (P < 0.05) of control values at the dose of 150 mg/kg per day without significant changes in other Ig isotypes. As IgG1 isotype is rarely cytotoxic and can act as a blocking antibody, it is suggested that the selective decrease in serum IgG1 induced by ginseng extract without changes in the cytotoxic antibodies such as IgG(2a) may be helpful for the prevention and inhibition of cancer.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalJournal of Ethnopharmacology
Volume58
Issue number1
DOIs
Publication statusPublished - 1997 Sep 1
Externally publishedYes

Fingerprint

Serum Globulins
Panax
gamma-Globulins
Oral Administration
Immunoglobulin G
Immunoglobulin Isotypes
Globulins
Blood Proteins
Albumins
Blocking Antibodies
Serum
Immunoglobulin A
Immunoglobulin M
Antibodies

Keywords

  • γ-globulin
  • Immunoglobulin isotype
  • Panax ginseng

ASJC Scopus subject areas

  • Pharmacology

Cite this

Long-term oral administration of ginseng extract decreases serum gamma-globulin and IgG1 isotype in mice. / Kim, Y. W.; Song, D. K.; Kim, W. H.; Lee, K. M.; Wie, M. B.; Kim, Y. H.; Kee, Sun-Ho; Cho, M. K.

In: Journal of Ethnopharmacology, Vol. 58, No. 1, 01.09.1997, p. 55-58.

Research output: Contribution to journalArticle

Kim, Y. W. ; Song, D. K. ; Kim, W. H. ; Lee, K. M. ; Wie, M. B. ; Kim, Y. H. ; Kee, Sun-Ho ; Cho, M. K. / Long-term oral administration of ginseng extract decreases serum gamma-globulin and IgG1 isotype in mice. In: Journal of Ethnopharmacology. 1997 ; Vol. 58, No. 1. pp. 55-58.
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