Long-term outcomes of NSAID-induced small intestinal injury assessed by capsule endoscopy in Korea: A nationwide multicenter retrospective study

The Korean Gut Image Study Group

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6±14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9±19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalGut and Liver
Volume9
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Capsule Endoscopy
Korea
Multicenter Studies
Anti-Inflammatory Agents
Retrospective Studies
Wounds and Injuries
Pharmaceutical Preparations
Aspirin
Registries
Databases
Aphthous Stomatitis
Recurrence
Non-Steroidal Anti-Inflammatory Agents
Hypertension

Keywords

  • Anti-inflammatory agents
  • Capsule endoscopy
  • Non-steroidal
  • Outcome

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Long-term outcomes of NSAID-induced small intestinal injury assessed by capsule endoscopy in Korea : A nationwide multicenter retrospective study. / The Korean Gut Image Study Group.

In: Gut and Liver, Vol. 9, No. 6, 01.01.2015, p. 727-733.

Research output: Contribution to journalArticle

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abstract = "Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6±14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0{\%}) presented with a history of aspirin use and an additional 49 (35.0{\%}) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6{\%}) and erosions or aphthae (n=32, 22.9{\%}). During the follow-up period (mean, 15.9±19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3{\%}). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.",
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T1 - Long-term outcomes of NSAID-induced small intestinal injury assessed by capsule endoscopy in Korea

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AU - The Korean Gut Image Study Group

AU - Shim, Ki Nam

AU - Song, Eun Mi

AU - Jeen, Yoon Tae

AU - Kim, Jin Oh

AU - Jeon, Seong Ran

AU - Chang, Dong Kyung

AU - Song, Hyun Joo

AU - Lim, Yun Jeong

AU - Kim, Jin Soo

AU - Ye, Byong Duk

AU - Park, Cheol Hee

AU - Jeon, Seong Woo

AU - Cheon, Jae Hee

AU - Lee, Kwang Jae

AU - Kim, Ji Hyun

AU - Jang, Byung Ik

AU - Moon, Jeong Seop

AU - Chun, Hoon-Jai

AU - Choi, Myung Gyu

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KW - Anti-inflammatory agents

KW - Capsule endoscopy

KW - Non-steroidal

KW - Outcome

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