Long-term outcomes of NSAID-induced small intestinal injury assessed by capsule endoscopy in Korea: A nationwide multicenter retrospective study

The Korean Gut Image Study Group

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6±14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9±19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.

    Original languageEnglish
    Pages (from-to)727-733
    Number of pages7
    JournalGut and liver
    Volume9
    Issue number6
    DOIs
    Publication statusPublished - 2015 Nov

    Keywords

    • Anti-inflammatory agents
    • Capsule endoscopy
    • Non-steroidal
    • Outcome

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

    Fingerprint

    Dive into the research topics of 'Long-term outcomes of NSAID-induced small intestinal injury assessed by capsule endoscopy in Korea: A nationwide multicenter retrospective study'. Together they form a unique fingerprint.

    Cite this