Long-term predictive factors of major adverse cardiac events in patients with acute myocardial infarction complication by cardiogenic shock

Eun Hui Bae, Sang Yup Lim, Myung Ho Jeong, Hyung Wook Park, Ji Hyun Lim, Young Joon Hong, Weon Kim, Ju Han Kim, Jeong Gwan Cho, Young Keun Ahn, Jong Chun Park, Soon Pal Suh, Byoung Hee Ahn, Sang Hyung Kim, Jung Chaee Kang

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Abstract

Background: Cardiogenic shock (CS) after acute myocardial infarction (AMI) develops in 5 ∼ 10% of patients and it is associated with high mortality. The aim of this study is to assess the predictive factors of mortality for patients with AMI and CS. Methods: Two hundred fifty five AMI patients with CS (the mean age was 66.0±11.0 years, M:F=156:99) out of 1,268 AMI patients who admitted at Chonnam National University Hospital between July 2000 and June 2002 were analyzed according to the clinical characteristics, coronary angiographic findings and MACE during admission and for the 1-year clinical follow-up. Results: Among the enrolled patients, 129 patients survived without MACE (Group I, mean age 64.2±10.6 years, M:F=76:53), and 126 patients had MACE (Group II, mean age 68.1±10.0 years, M:F=80:46) during admission or during the 1-year follow-up period. There were significant differences in age between the Groups I and II (64.2±10.6 vs. 68.1±11.0 years, respectively, p=0.004) and the previous MI history (0 vs. 17.4%, respectively, p<0.001). The left ventricular ejection fraction (EF) was lower in Group II (Group I vs. II: 49.1±13.0 vs. 39.1±12.9%, p<0.001). The levels of troponin (Tn) I and C-reactive protein (CRP) were higher in Group II (Group I vs. II: 29.2±7.72 vs. 50.8±5.17 ng/dL, p=0.017, 3.8±0.48 vs. 9.9±1.21 mg/dL, p<0.001 respectively). Left main stem lesion (LMSL) was more common in Group II than in Group I (0.7% vs. 22.0%, respectively, p=0.004). In-hospital death was associated with low Thrombolysis In Myocardial Infarction (TIMI) flow after coronary revascularization. Conclusion: Old age, a previous MI history, high Tn and CRP, low EF and LMSL are associated with higher MACE for patients with AMI and CS. Coronary revascularization with TIMI 3 flow lowers the in-hospital mortality.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalKorean Journal of Internal Medicine
Volume20
Issue number1
DOIs
Publication statusPublished - 2005 Mar

Keywords

  • Coronary diseases
  • Myocardial infarction
  • Prognosis
  • Shock

ASJC Scopus subject areas

  • Internal Medicine

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    Bae, E. H., Lim, S. Y., Jeong, M. H., Park, H. W., Lim, J. H., Hong, Y. J., Kim, W., Kim, J. H., Cho, J. G., Ahn, Y. K., Park, J. C., Suh, S. P., Ahn, B. H., Kim, S. H., & Kang, J. C. (2005). Long-term predictive factors of major adverse cardiac events in patients with acute myocardial infarction complication by cardiogenic shock. Korean Journal of Internal Medicine, 20(1), 8-14. https://doi.org/10.3904/kjim.2005.20.1.8