Long-term prognosis of anti-neutrophil cytoplasmic antibody-negative renal vasculitis: Cohort study in Korea

Sung Woo Lee, Mi Yeon Yu, Seon Ha Baek, Shin Young Ahn, Sejoong Kim, Ki Young Na, Dong Wan Chae, Ho Jun Chin

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    2 Citations (Scopus)


    Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Coxproportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.

    Original languageEnglish
    Pages (from-to)542-546
    Number of pages5
    JournalJournal of Korean medical science
    Issue number4
    Publication statusPublished - 2016


    • Anti-neutrophil cytoplasmic antibody (ANCA)
    • Chronic
    • Cohort studies
    • Kidney failure
    • Koreans
    • Mortality
    • Prognosis
    • Proteinuria
    • Sex
    • Survival
    • Vasculitis

    ASJC Scopus subject areas

    • Medicine(all)


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