Long-term prognosis of anti-neutrophil cytoplasmic antibody-negative renal vasculitis: Cohort study in Korea

Sung Woo Lee, Mi Yeon Yu, Seon Ha Baek, Shin Young Ahn, Sejoong Kim, Ki Young Na, Dong Wan Chae, Ho Jun Chin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7% of patients progressed to end stage renal disease (ESRD) and 43.8% died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Coxproportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95% confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.

Original languageEnglish
Pages (from-to)542-546
Number of pages5
JournalJournal of Korean Medical Science
Volume31
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Fingerprint

Antineutrophil Cytoplasmic Antibodies
Korea
Vasculitis
Cohort Studies
Kidney
Chronic Kidney Failure
Kaplan-Meier Estimate
Indirect Fluorescent Antibody Technique
Survival Analysis

Keywords

  • Anti-neutrophil cytoplasmic antibody (ANCA)
  • Chronic
  • Cohort studies
  • Kidney failure
  • Koreans
  • Mortality
  • Prognosis
  • Proteinuria
  • Sex
  • Survival
  • Vasculitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Long-term prognosis of anti-neutrophil cytoplasmic antibody-negative renal vasculitis : Cohort study in Korea. / Lee, Sung Woo; Yu, Mi Yeon; Baek, Seon Ha; Ahn, Shin Young; Kim, Sejoong; Na, Ki Young; Chae, Dong Wan; Chin, Ho Jun.

In: Journal of Korean Medical Science, Vol. 31, No. 4, 01.01.2016, p. 542-546.

Research output: Contribution to journalArticle

Lee, Sung Woo ; Yu, Mi Yeon ; Baek, Seon Ha ; Ahn, Shin Young ; Kim, Sejoong ; Na, Ki Young ; Chae, Dong Wan ; Chin, Ho Jun. / Long-term prognosis of anti-neutrophil cytoplasmic antibody-negative renal vasculitis : Cohort study in Korea. In: Journal of Korean Medical Science. 2016 ; Vol. 31, No. 4. pp. 542-546.
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abstract = "Few studies have reported on the long-term prognosis of anti-neutrophil cytoplasmic antibody (ANCA)-negative renal vasculitis. Between April 2003 and December 2013, 48 patients were diagnosed with renal vasculitis. Their ANCA status was tested using indirect immunofluorescence and enzyme-linked immunosorbent assays. During a median (interquartile range) follow-up duration of 933.5 (257.5-2,079.0) days, 41.7{\%} of patients progressed to end stage renal disease (ESRD) and 43.8{\%} died from any cause. Of 48 patients, 6 and 42 were ANCA-negative and positive, respectively. The rate of ESRD within 3 months was higher in ANCA-negative patients than in ANCA-positive patients (P = 0.038). In Kaplan-Meier survival analysis, ANCA-negative patients showed shorter renal survival than did ANCA-positive patients (log-rank P = 0.033). In univariate Coxproportional hazard regression analysis, ANCA-negative patients showed increased risk of ESRD, with a hazard ratio 3.190 (95{\%} confidence interval, 1.028-9.895, P = 0.045). However, the effect of ANCA status on renal survival was not statistically significant in multivariate analysis. Finally, ANCA status did not significantly affect patient survival. In conclusion, long-term patient and renal survival of ANCA-negative renal vasculitis patients did not differ from those of ANCA-positive renal vasculitis patients. Therefore, different treatment strategy depending on ANCA status might be unnecessary.",
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