Long-term results of percutaneous ethanol injection for the treatment of hepatocellular carcinoma in Korea

Mi Sung Yon, Dongil Choi, Hyo K. Lim, Jae Lee Won, Hoon Kim Seung, Ju Kim Min, Woon Paik Seung, Chul Yoo Byung, Cheol Koh Kwang, Hyoek Lee Joon, Seok Choi Moon

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Objective: To evaluate the long-term follow-up results of percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) in Korea. Materials and Methods: Sixty-eight nodular HCCs initially detected in 64 patients, were subjected to US-guided PEI as a first-line treatment. Long-term survival rates, local tumor progression rates, and complications were evaluated, as were the influences of tumor size and Child-Pugh class on these variables. Results: No major complications occurred. The overall survival rates of the 64 patients at three and five years were 71% and 39%, and their cancer-free survival rates were 22% and 15%, respectively. The overall survival rate of patients with a small HCC (≤ 2 cm) was significantly higher (p = 0.014) than that of patients with a medium-sized HCC (≤ 2 cm). The overall survival rate of patients with Child-Pugh class A was significantly higher (p = 0.049) than that of patients with Child-Pugh class B. Of 59 cases with no residual tumor, local tumor progression was observed in ablation zones in 18, and this was not found to be significantly influenced by tumor size or Child-Pugh class. Conclusion: The results of our investigation of the long-term survival rates of PEI in HCC patients in Korea (a hepatitis B virus-endemic area) were consistent with those reported previously in hepatitis C endemic areas. Patients with a smaller tumor or a better liver function exhibited superior survival rates.

    Original languageEnglish
    Pages (from-to)187-192
    Number of pages6
    JournalKorean journal of radiology
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Alcohol ablation
    • Liver neoplasms, therapy
    • Liver, neoplasms

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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