Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats: An experimenter blind, randomized controlled study

Bum-Chul Yoon, Mee Young Kim, Yong Gwon Byun, So Young Ha, Bong Suk Han, Joshua H. You, Chung Ju Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated a long-term exercise-induced neuroplasticity and spatial memory recovery in 15 rats in a treadmill as follows: normal control rats (NC), streptozotocin (STZ)-induced diabetic control rats (DC), and STZ-induced diabetic rats exercising in a treadmill (DE). As per the DE group, the running exercise in a treadmill was administered for 30 minutes a day for 6 weeks. Neuronal immediate-early gene (IEG) expression (c-Fos) in the hippocampus and radial arm maze (RAM) tests were measured and revealed that the c-Fos levels in DE were significantly higher than those in NC and DC (p < 0.05). Behavioral data analysis indicated that spatial memory performance scores, obtained from the RAM test, were significantly different among the three groups (p < 0.05). The memory scores of NC and DE were higher than those of DC (p < 0.05). These findings suggest that exercising in the treadmill increased neuronal immediate-early gene expression associated with neuroplasticity, thereby improving spatial memory. This is the first experimental evidence in literature that supports the efficacy of exercise-induced neuroplasticity and spatial motor memory in diabetes care.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalNeuroRehabilitation
Volume24
Issue number3
DOIs
Publication statusPublished - 2009 Jul 31

Fingerprint

Neuronal Plasticity
Streptozocin
Immediate-Early Genes
Gene Expression
Running
Hippocampus
Spatial Memory

Keywords

  • C-Fos
  • Diabetes mellitus
  • Hippocampus
  • Neuroplasticity
  • Rats
  • Spatial memory
  • Treadmill exercise

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology

Cite this

Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats : An experimenter blind, randomized controlled study. / Yoon, Bum-Chul; Kim, Mee Young; Byun, Yong Gwon; Ha, So Young; Han, Bong Suk; You, Joshua H.; Kim, Chung Ju.

In: NeuroRehabilitation, Vol. 24, No. 3, 31.07.2009, p. 291-297.

Research output: Contribution to journalArticle

Yoon, Bum-Chul ; Kim, Mee Young ; Byun, Yong Gwon ; Ha, So Young ; Han, Bong Suk ; You, Joshua H. ; Kim, Chung Ju. / Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats : An experimenter blind, randomized controlled study. In: NeuroRehabilitation. 2009 ; Vol. 24, No. 3. pp. 291-297.
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