Longitudinal associations between micronutrient consumption and leukocyte telomere length

J. Y. Lee, Chol Shin, I. Baik

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.

Original languageEnglish
Pages (from-to)236-243
Number of pages8
JournalJournal of Human Nutrition and Dietetics
Volume30
Issue number2
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

Micronutrients
Telomere
Leukocytes
Folic Acid
Potassium
Ascorbic Acid
Food
Vitamin B Complex
Thiamine
Vitamin A
Vegetables
Phosphorus
Zinc
Real-Time Polymerase Chain Reaction
Fruit
Oxidative Stress
Carbon
Iron
Antioxidants
Calcium

Keywords

  • antioxidant
  • folate
  • leukocyte telomere length
  • nutritional genomics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Longitudinal associations between micronutrient consumption and leukocyte telomere length. / Lee, J. Y.; Shin, Chol; Baik, I.

In: Journal of Human Nutrition and Dietetics, Vol. 30, No. 2, 01.04.2017, p. 236-243.

Research output: Contribution to journalArticle

@article{23f608e6185540da875a23ab84c1611a,
title = "Longitudinal associations between micronutrient consumption and leukocyte telomere length",
abstract = "Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.",
keywords = "antioxidant, folate, leukocyte telomere length, nutritional genomics",
author = "Lee, {J. Y.} and Chol Shin and I. Baik",
year = "2017",
month = "4",
day = "1",
doi = "10.1111/jhn.12403",
language = "English",
volume = "30",
pages = "236--243",
journal = "Journal of Human Nutrition and Dietetics",
issn = "0952-3871",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Longitudinal associations between micronutrient consumption and leukocyte telomere length

AU - Lee, J. Y.

AU - Shin, Chol

AU - Baik, I.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.

AB - Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.

KW - antioxidant

KW - folate

KW - leukocyte telomere length

KW - nutritional genomics

UR - http://www.scopus.com/inward/record.url?scp=85014685021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014685021&partnerID=8YFLogxK

U2 - 10.1111/jhn.12403

DO - 10.1111/jhn.12403

M3 - Article

C2 - 27550625

AN - SCOPUS:85014685021

VL - 30

SP - 236

EP - 243

JO - Journal of Human Nutrition and Dietetics

JF - Journal of Human Nutrition and Dietetics

SN - 0952-3871

IS - 2

ER -