Abstract
Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.
| Original language | English |
|---|---|
| Pages (from-to) | 236-243 |
| Number of pages | 8 |
| Journal | Journal of Human Nutrition and Dietetics |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 Apr 1 |
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Keywords
- antioxidant
- folate
- leukocyte telomere length
- nutritional genomics
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Longitudinal associations between micronutrient consumption and leukocyte telomere length. / Lee, J. Y.; Shin, Chol; Baik, I.
In: Journal of Human Nutrition and Dietetics, Vol. 30, No. 2, 01.04.2017, p. 236-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Longitudinal associations between micronutrient consumption and leukocyte telomere length
AU - Lee, J. Y.
AU - Shin, Chol
AU - Baik, I.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.
AB - Background: There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length (LTL). Methods: The study included 1958 middle-aged and older Korean men and women (age range at baseline: 40–69 years) from a population-based cohort. We collected dietary information at baseline using a semiquantitative food frequency questionnaire (June 2001 to January 2003) and assessed the consumption of micronutrients, including vitamins A, B1, B2, B3, B6, B9 (folate), C and E, as well as calcium, phosphorus, potassium, iron and zinc. We measured LTL using a real-time polymerase chain reaction at the 10-year follow-up examination (February 2011 to November 2012). Results: In the multiple regression model adjusted for potential confounders, LTL was positively associated with the consumption of vitamin C (P < 0.05), folate (P = 0.05) and potassium (P = 0.05) in all participants. In the age-stratified analysis, the association between the consumption of vitamin C (P < 0.01), folate (P < 0.05) and potassium (P < 0.05) with LTL was significant only among participants aged <50 years. Conclusions: Our findings suggest that the earlier consumption of vitamin C, folate and potassium, which are abundant in fruits and vegetables, can delay biological ageing in middle-aged and older adults.
KW - antioxidant
KW - folate
KW - leukocyte telomere length
KW - nutritional genomics
UR - http://www.scopus.com/inward/record.url?scp=85014685021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014685021&partnerID=8YFLogxK
U2 - 10.1111/jhn.12403
DO - 10.1111/jhn.12403
M3 - Article
C2 - 27550625
AN - SCOPUS:85014685021
VL - 30
SP - 236
EP - 243
JO - Journal of Human Nutrition and Dietetics
JF - Journal of Human Nutrition and Dietetics
SN - 0952-3871
IS - 2
ER -