Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease

Jae Seung Lee, Seon Ok Kim, Joon Beom Seo, Ji Hyun Lee, Eun Kyung Kim, Tae Hyung Kim, Woo Jin Kim, Jin Hwa Lee, Sang Min Lee, Sang Yeub Lee, Seong Yong Lim, Tae Rim Shin, Ho Il Yoon, Sei Won Lee, Jin Won Huh, Yeon Mok Oh, Sang Do Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.

Original languageEnglish
Pages (from-to)405-412
Number of pages8
JournalLung
Volume191
Issue number4
DOIs
Publication statusPublished - 2013 Aug 1

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Total Lung Capacity
Inspiratory Capacity
Chronic Obstructive Pulmonary Disease
Lung
Bronchodilator Agents
Forced Expiratory Volume
Residual Volume
Vital Capacity
Functional Residual Capacity
Dyspnea
Biomedical Research
Comorbidity
Logistic Models
Regression Analysis

Keywords

  • Chronic obstructive pulmonary disease
  • Inspiratory capacity
  • Lung volume measurements
  • Spirometry
  • Total lung capacity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lee, J. S., Kim, S. O., Seo, J. B., Lee, J. H., Kim, E. K., Kim, T. H., ... Lee, S. D. (2013). Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease. Lung, 191(4), 405-412. https://doi.org/10.1007/s00408-013-9478-0

Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease. / Lee, Jae Seung; Kim, Seon Ok; Seo, Joon Beom; Lee, Ji Hyun; Kim, Eun Kyung; Kim, Tae Hyung; Kim, Woo Jin; Lee, Jin Hwa; Lee, Sang Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Lee, Sei Won; Huh, Jin Won; Oh, Yeon Mok; Lee, Sang Do.

In: Lung, Vol. 191, No. 4, 01.08.2013, p. 405-412.

Research output: Contribution to journalArticle

Lee, JS, Kim, SO, Seo, JB, Lee, JH, Kim, EK, Kim, TH, Kim, WJ, Lee, JH, Lee, SM, Lee, SY, Lim, SY, Shin, TR, Yoon, HI, Lee, SW, Huh, JW, Oh, YM & Lee, SD 2013, 'Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease', Lung, vol. 191, no. 4, pp. 405-412. https://doi.org/10.1007/s00408-013-9478-0
Lee, Jae Seung ; Kim, Seon Ok ; Seo, Joon Beom ; Lee, Ji Hyun ; Kim, Eun Kyung ; Kim, Tae Hyung ; Kim, Woo Jin ; Lee, Jin Hwa ; Lee, Sang Min ; Lee, Sang Yeub ; Lim, Seong Yong ; Shin, Tae Rim ; Yoon, Ho Il ; Lee, Sei Won ; Huh, Jin Won ; Oh, Yeon Mok ; Lee, Sang Do. / Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease. In: Lung. 2013 ; Vol. 191, No. 4. pp. 405-412.
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abstract = "Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 {\%}/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.",
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T1 - Longitudinal lung volume changes in patients with chronic obstructive pulmonary disease

AU - Lee, Jae Seung

AU - Kim, Seon Ok

AU - Seo, Joon Beom

AU - Lee, Ji Hyun

AU - Kim, Eun Kyung

AU - Kim, Tae Hyung

AU - Kim, Woo Jin

AU - Lee, Jin Hwa

AU - Lee, Sang Min

AU - Lee, Sang Yeub

AU - Lim, Seong Yong

AU - Shin, Tae Rim

AU - Yoon, Ho Il

AU - Lee, Sei Won

AU - Huh, Jin Won

AU - Oh, Yeon Mok

AU - Lee, Sang Do

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N2 - Background: The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). Methods: The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. Results: The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. Conclusion: MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.

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KW - Chronic obstructive pulmonary disease

KW - Inspiratory capacity

KW - Lung volume measurements

KW - Spirometry

KW - Total lung capacity

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