Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging

Yasheng Chen, Hongyu An, Hongtu Zhu, Valerie Jewells, Diane Armao, Dinggang Shen, John H. Gilmore, Weili Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Although diffusion tensor imaging (DTI) has provided substantial insights into early brain development, most DTI studies based on fractional anisotropy (FA) and mean diffusivity (MD) may not capitalize on the information derived from the three principal diffusivities (e.g. eigenvalues). In this study, we explored the spatial and temporal evolution of white matter structures during early brain development using two geometrical diffusion measures, namely, linear (Cl) and planar (Cp) diffusion anisotropies, from 71 longitudinal datasets acquired from 29 healthy, full-term pediatric subjects. The growth trajectories were estimated with generalized estimating equations (GEE) using linear fitting with logarithm of age (days). The presence of the white matter structures in Cl and Cp was observed in neonates, suggesting that both the cylindrical and fanning or crossing structures in various white matter regions may already have been formed at birth. Moreover, we found that both Cl and Cp evolved in a temporally nonlinear and spatially inhomogeneous manner. The growth velocities of Cl in central white matter were significantly higher when compared to peripheral, or more laterally located, white matter: central growth velocity Cl=0.0465±0.0273/log(days), versus peripheral growth velocity Cl=0.0198±0.0127/log(days), p<10 -6. In contrast, the growth velocities of Cp in central white matter were significantly lower than that in peripheral white matter: central growth velocity Cp=0.0014±0.0058/log(days), versus peripheral growth velocity Cp=0.0289±0.0101/log(days), p<10 -6. which is analyzed, our findings suggest that ongoing physiologic and microstructural changes in the developing brain may exert different effects on the temporal evolution of these two geometrical diffusion measures. Thus, future studies utilizing DTI with correlative histological analysis in the study of early brain development are warranted.

Original languageEnglish
Pages (from-to)993-1005
Number of pages13
JournalNeuroImage
Volume58
Issue number4
DOIs
Publication statusPublished - 2011 Oct 15
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Regression Analysis
Brain
Growth
Anisotropy
White Matter
Parturition
Pediatrics

Keywords

  • Brain growth
  • DTI
  • Early brain development
  • GEE
  • Geometrical diffusion measures
  • Longitudinal analysis

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging. / Chen, Yasheng; An, Hongyu; Zhu, Hongtu; Jewells, Valerie; Armao, Diane; Shen, Dinggang; Gilmore, John H.; Lin, Weili.

In: NeuroImage, Vol. 58, No. 4, 15.10.2011, p. 993-1005.

Research output: Contribution to journalArticle

Chen, Yasheng ; An, Hongyu ; Zhu, Hongtu ; Jewells, Valerie ; Armao, Diane ; Shen, Dinggang ; Gilmore, John H. ; Lin, Weili. / Longitudinal regression analysis of spatial-temporal growth patterns of geometrical diffusion measures in early postnatal brain development with diffusion tensor imaging. In: NeuroImage. 2011 ; Vol. 58, No. 4. pp. 993-1005.
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