Loop diuretics in clinical practice

Se Won Oh, Sang Youb Han

    Research output: Contribution to journalReview articlepeer-review

    63 Citations (Scopus)

    Abstract

    Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must be considered when prescribing this medicine: (1) oral versus intravenous treatment, (2) dosage, (3) continuous versus bolus infusion, (4) application in chronic kidney disease patients, and (5) side effects. The bioavailability of furosemide differs between oral and intravenous therapy. Additionally, the threshold and ceiling doses of furosemide differ according to the particular clinical condition of the patient, for example in patients with severe edema or chronic kidney disease. To maximize the efficiency of furosemide, a clear understanding of how the mode of delivery will impact bioavailability and the required dosage is necessary.

    Original languageEnglish
    Pages (from-to)17-21
    Number of pages5
    JournalElectrolyte and Blood Pressure
    Volume13
    Issue number1
    DOIs
    Publication statusPublished - 2015 Jun 1

    Keywords

    • Chronic kidney disease
    • Furosemide
    • Loop diuretics

    ASJC Scopus subject areas

    • Internal Medicine
    • Physiology
    • Cardiology and Cardiovascular Medicine

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