TY - JOUR
T1 - Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization
AU - Lee, Jiyun
AU - Wang, Jianzhou
AU - Torbenson, Michael
AU - Lu, You
AU - Liu, Qiong Z.
AU - Li, Shibo
PY - 2010/1/15
Y1 - 2010/1/15
N2 - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.
AB - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.
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U2 - 10.1016/j.cancergencyto.2009.09.005
DO - 10.1016/j.cancergencyto.2009.09.005
M3 - Article
C2 - 20082856
AN - SCOPUS:71649113569
SN - 0165-4608
VL - 196
SP - 179
EP - 183
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
