Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Ji-Yun Lee, Jianzhou Wang, Michael Torbenson, You Lu, Qiong Z. Liu, Shibo Li

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume196
Issue number2
DOIs
Publication statusPublished - 2010 Jan 15
Externally publishedYes

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Phyllodes Tumor
Comparative Genomic Hybridization
Hereditary Neoplastic Syndromes
Breast Neoplasms
Gastrointestinal Stromal Tumors
Tumor Suppressor Genes
Genes
Breast
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. / Lee, Ji-Yun; Wang, Jianzhou; Torbenson, Michael; Lu, You; Liu, Qiong Z.; Li, Shibo.

In: Cancer Genetics and Cytogenetics, Vol. 196, No. 2, 15.01.2010, p. 179-183.

Research output: Contribution to journalArticle

Lee, Ji-Yun ; Wang, Jianzhou ; Torbenson, Michael ; Lu, You ; Liu, Qiong Z. ; Li, Shibo. / Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. In: Cancer Genetics and Cytogenetics. 2010 ; Vol. 196, No. 2. pp. 179-183.
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