Low bone mineral density is associated with metabolic syndrome in South Korean men but not in women: The 2008-2010 Korean National Health and Nutrition Examination Survey

Yang-Hyun Kim, Kyung-Hwan Cho, Youn Seon Choi, Seon Mee Kim, Ga Eun Nam, Seung Hwan Lee, Byung Joon Ko, Yong Gyu Park, Kyung Do Han, Kyung Shik Lee, Do-Hoon Kim

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Abstract

We examined the relationships between bone mineral density (BMD) and metabolic syndrome in 6,659 men and 7,826 women from South Korean. After adjusting for age, body mass index (BMI), tobacco and alcohol use, and regular exercise, low BMD is especially associated with metabolic syndrome in South Korean men. Purpose: This study examined the relationships between BMD and metabolic syndrome (MS) in South Korean adults. Methods: A total of 14,485 adults (6,659 men and 7,826 women) in the Korea National Health and Nutrition Examination Survey conducted from 2008 to 2010 were analyzed. We used multivariable regression models to examine the relationship between low BMD and MS. We calculated homeostasis model assessment and insulin resistance (HOMA-IR). MS was defined according to AHA/NHLBI criteria for Asians. BMD was measured at the lumbar spine (LS), femur neck (FN), total hip (TH), trochanter, and intertrochanter. Results: After adjustment for age, BMI, tobacco and alcohol use, and regular exercise, the TH and FN BMD were significantly lower in men with MS than in men without MS (p < 0.05). However, there were no differences in premenopausal and postmenopausal women. In men, BMD was positively correlated with BMI, and high density lipoprotein cholesterol, but was negatively correlated with insulin, HOMA-IR, and triglyceride at all three sites (p < 0.05). Along with an increase of BMD (0.1 g/cm2), the odds ratios (ORs) for obesity and abdominal obesity were all greater than 1 at all sites in both genders. The ORs for hypertension and MS were 0.937 (0.879-0.998) and 0.899 (0.840-0.962), respectively at FN, and the OR for diabetes mellitus was 1.103 (1.017-1.196) at LS in men. In postmenopausal women, the OR for hypertension was 1.133 (1.029-1.246) at LS. Conclusions: Low BMD was especially associated with MS in South Korean men.

Original languageEnglish
Article number142
JournalArchives of Osteoporosis
Volume8
Issue number1-2
DOIs
Publication statusPublished - 2013 May 30

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Nutrition Surveys
Bone Density
Femur Neck
Odds Ratio
Spine
Body Mass Index
Tobacco Use
Insulin Resistance
Hip
Homeostasis
Alcohols
Exercise
Hypertension
National Heart, Lung, and Blood Institute (U.S.)
Abdominal Obesity
Korea
Femur
HDL Cholesterol
Diabetes Mellitus
Triglycerides

Keywords

  • Bone mineral density
  • Insulin resistance
  • Metabolic syndrome
  • Osteoporosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Low bone mineral density is associated with metabolic syndrome in South Korean men but not in women : The 2008-2010 Korean National Health and Nutrition Examination Survey. / Kim, Yang-Hyun; Cho, Kyung-Hwan; Choi, Youn Seon; Kim, Seon Mee; Nam, Ga Eun; Lee, Seung Hwan; Ko, Byung Joon; Park, Yong Gyu; Han, Kyung Do; Lee, Kyung Shik; Kim, Do-Hoon.

In: Archives of Osteoporosis, Vol. 8, No. 1-2, 142, 30.05.2013.

Research output: Contribution to journalArticle

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abstract = "We examined the relationships between bone mineral density (BMD) and metabolic syndrome in 6,659 men and 7,826 women from South Korean. After adjusting for age, body mass index (BMI), tobacco and alcohol use, and regular exercise, low BMD is especially associated with metabolic syndrome in South Korean men. Purpose: This study examined the relationships between BMD and metabolic syndrome (MS) in South Korean adults. Methods: A total of 14,485 adults (6,659 men and 7,826 women) in the Korea National Health and Nutrition Examination Survey conducted from 2008 to 2010 were analyzed. We used multivariable regression models to examine the relationship between low BMD and MS. We calculated homeostasis model assessment and insulin resistance (HOMA-IR). MS was defined according to AHA/NHLBI criteria for Asians. BMD was measured at the lumbar spine (LS), femur neck (FN), total hip (TH), trochanter, and intertrochanter. Results: After adjustment for age, BMI, tobacco and alcohol use, and regular exercise, the TH and FN BMD were significantly lower in men with MS than in men without MS (p < 0.05). However, there were no differences in premenopausal and postmenopausal women. In men, BMD was positively correlated with BMI, and high density lipoprotein cholesterol, but was negatively correlated with insulin, HOMA-IR, and triglyceride at all three sites (p < 0.05). Along with an increase of BMD (0.1 g/cm2), the odds ratios (ORs) for obesity and abdominal obesity were all greater than 1 at all sites in both genders. The ORs for hypertension and MS were 0.937 (0.879-0.998) and 0.899 (0.840-0.962), respectively at FN, and the OR for diabetes mellitus was 1.103 (1.017-1.196) at LS in men. In postmenopausal women, the OR for hypertension was 1.133 (1.029-1.246) at LS. Conclusions: Low BMD was especially associated with MS in South Korean men.",
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T2 - The 2008-2010 Korean National Health and Nutrition Examination Survey

AU - Kim, Yang-Hyun

AU - Cho, Kyung-Hwan

AU - Choi, Youn Seon

AU - Kim, Seon Mee

AU - Nam, Ga Eun

AU - Lee, Seung Hwan

AU - Ko, Byung Joon

AU - Park, Yong Gyu

AU - Han, Kyung Do

AU - Lee, Kyung Shik

AU - Kim, Do-Hoon

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KW - Bone mineral density

KW - Insulin resistance

KW - Metabolic syndrome

KW - Osteoporosis

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