Low diastolic blood pressure and cognitive decline in korean elderly people: The korean longitudinal study on cognitive aging and dementia

Dongyun Lee, Bong Jo Kim, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young Park, Joon Hyuk Park, Seonjeong Byun, Seung Wan Suh, Ji Young Seo, Yoonseop So, Seung Ho Ryu, Jong Chul Youn, Kyoung Hwan Lee, Dong Young LeeDong Woo Lee, Seok Bum Lee, Jung Jae Lee, Ju Ri Lee, Hyeon Jeong, Hyun Ghang Jeong, Jin Hyeong Jhoo, Kyuhee Han, Jong Woo Hong, Jong Bin Bae, Ki Woong Kim

Research output: Contribution to journalArticle

Abstract

Objective Cardiovascular diseases are representative risk factors for the onset of cognitive decline. The purpose of this study was to confirm the relationship between diastolic blood pressure and cognitive function in elderly people in Korea. Methods Data from subjects who were enrolled in the prospective Korean Longitudinal Study on Cognitive Aging and Dementia were used in this study. Data from 701 subjects whose diastolic blood pressure range did not change (≤79 mm Hg or ≥80 mm Hg) over 2 years were analyzed. To analyze the differences in cognitive function between the groups at the 2-year follow-up, an analysis of covariance was performed with covariates, which were significantly different between the two groups, and the baseline cognitive function. Results Significant differences were observed between the two groups, and the mean scores on the constructional praxis (η2=0.010) and word list recall tests (η2=0.018) in the diastolic blood pressure ≥80 mm Hg group were higher than those in the diastolic blood pressure ≤79 mm Hg group at the 2-year follow-up. Conclusion These results indicate that maintaining a DBP below 79 mm Hg presents a greater risk of cognitive decline in Korean elderly people.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalPsychiatry Investigation
Volume17
Issue number1
DOIs
Publication statusPublished - 2020 Jan

Keywords

  • Cognition
  • Diastolic blood pressure
  • Senility

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Lee, D., Kim, B. J., Han, J. W., Kim, T. H., Kwak, K. P., Kim, K., Kim, S. G., Kim, J. L., Kim, T. H., Moon, S. W., Park, J. Y., Park, J. H., Byun, S., Suh, S. W., Seo, J. Y., So, Y., Ryu, S. H., Youn, J. C., Lee, K. H., ... Kim, K. W. (2020). Low diastolic blood pressure and cognitive decline in korean elderly people: The korean longitudinal study on cognitive aging and dementia. Psychiatry Investigation, 17(1), 21-28. https://doi.org/10.30773/pi.2019.0105