Low-dose versus moderate-dose atorvastatin after acute myocardial infarction

8-Month effects on coronary flow reserve and angiogenic cell mobilisation

Soon Jun Hong, Seung Cheol Choi, Jae Sang Kim, Wan Joo Shim, Seong-Mi Park, Chul Min Ahn, Jae Hyung Park, Yong Hyun Kim, Do-Sun Lim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To compare the effects of atorvastatin 10 mg versus 40 mg in circulating angiogenic cell mobilisations and in restoring coronary flow reserve (CFR) during the 8-month follow-up in patients with a first acute myocardial infarction (AMI). Design: CFR was measured using an intracoronary Doppler wire in 102 patients with AMI at baseline and at 8 months. Changes in the absolute number of circulating angiogenic cells were measured at baseline, 1 day, 5 days and at 8 months. Stented patients were randomly assigned to either low-dose atorvastatin 10 mg (ATOR10, n=52) or moderate-dose atorvastatin 40 mg (ATOR40, n=50). Setting: University Hospital. Results: CFR increased significantly in both groups during the 8-month follow-up. The 8-month increases from baseline in CFR were significantly greater in the ATOR40 group than in the ATOR10 group (0.99±0.69 vs 0.55±0.47, p=0.017, respectively). The serial increases in the absolute number of CD34+ and CXCR4+ cells were significantly greater in the ATOR40 group, especially at 24 h after the procedure (two-way repeated-measures analysis of variance: p=0.046 and p=0.022, respectively). Decreases from baseline for interleukin 6 (-2.94±3.31 vs -1.52±2.82 pg/ml), tumour necrosis factor α (-1.31±2.96 vs -0.01±1.29 pg/ml), soluble intercellular adhesion molecule-1 (-71±95 vs 37±83 ng/ml) and soluble vascular cell adhesion molecule-1 (-51±364 vs 190±204 ng/ml) were significantly greater in the ATOR40 group. Conclusions: The recovery of microvascular integrity after acute ischaemic injury in the ATOR40 group was expedited by greater circulating angiogenic cell mobilisations such as CD34+ and CXCR4+ cells, together with greater decreases in inflammatory cytokines and low-density lipoprotein- cholesterol concentrations. Registration number: http://ClinicalTrials.gov number, NCT00536887.

Original languageEnglish
Pages (from-to)756-764
Number of pages9
JournalHeart
Volume96
Issue number10
DOIs
Publication statusPublished - 2010 May 1

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Myocardial Infarction
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
LDL Cholesterol
Interleukin-6
Analysis of Variance
Tumor Necrosis Factor-alpha
Atorvastatin Calcium
Cytokines
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Low-dose versus moderate-dose atorvastatin after acute myocardial infarction : 8-Month effects on coronary flow reserve and angiogenic cell mobilisation. / Hong, Soon Jun; Choi, Seung Cheol; Kim, Jae Sang; Shim, Wan Joo; Park, Seong-Mi; Ahn, Chul Min; Park, Jae Hyung; Kim, Yong Hyun; Lim, Do-Sun.

In: Heart, Vol. 96, No. 10, 01.05.2010, p. 756-764.

Research output: Contribution to journalArticle

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abstract = "Objective: To compare the effects of atorvastatin 10 mg versus 40 mg in circulating angiogenic cell mobilisations and in restoring coronary flow reserve (CFR) during the 8-month follow-up in patients with a first acute myocardial infarction (AMI). Design: CFR was measured using an intracoronary Doppler wire in 102 patients with AMI at baseline and at 8 months. Changes in the absolute number of circulating angiogenic cells were measured at baseline, 1 day, 5 days and at 8 months. Stented patients were randomly assigned to either low-dose atorvastatin 10 mg (ATOR10, n=52) or moderate-dose atorvastatin 40 mg (ATOR40, n=50). Setting: University Hospital. Results: CFR increased significantly in both groups during the 8-month follow-up. The 8-month increases from baseline in CFR were significantly greater in the ATOR40 group than in the ATOR10 group (0.99±0.69 vs 0.55±0.47, p=0.017, respectively). The serial increases in the absolute number of CD34+ and CXCR4+ cells were significantly greater in the ATOR40 group, especially at 24 h after the procedure (two-way repeated-measures analysis of variance: p=0.046 and p=0.022, respectively). Decreases from baseline for interleukin 6 (-2.94±3.31 vs -1.52±2.82 pg/ml), tumour necrosis factor α (-1.31±2.96 vs -0.01±1.29 pg/ml), soluble intercellular adhesion molecule-1 (-71±95 vs 37±83 ng/ml) and soluble vascular cell adhesion molecule-1 (-51±364 vs 190±204 ng/ml) were significantly greater in the ATOR40 group. Conclusions: The recovery of microvascular integrity after acute ischaemic injury in the ATOR40 group was expedited by greater circulating angiogenic cell mobilisations such as CD34+ and CXCR4+ cells, together with greater decreases in inflammatory cytokines and low-density lipoprotein- cholesterol concentrations. Registration number: http://ClinicalTrials.gov number, NCT00536887.",
author = "Hong, {Soon Jun} and Choi, {Seung Cheol} and Kim, {Jae Sang} and Shim, {Wan Joo} and Seong-Mi Park and Ahn, {Chul Min} and Park, {Jae Hyung} and Kim, {Yong Hyun} and Do-Sun Lim",
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T1 - Low-dose versus moderate-dose atorvastatin after acute myocardial infarction

T2 - 8-Month effects on coronary flow reserve and angiogenic cell mobilisation

AU - Hong, Soon Jun

AU - Choi, Seung Cheol

AU - Kim, Jae Sang

AU - Shim, Wan Joo

AU - Park, Seong-Mi

AU - Ahn, Chul Min

AU - Park, Jae Hyung

AU - Kim, Yong Hyun

AU - Lim, Do-Sun

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N2 - Objective: To compare the effects of atorvastatin 10 mg versus 40 mg in circulating angiogenic cell mobilisations and in restoring coronary flow reserve (CFR) during the 8-month follow-up in patients with a first acute myocardial infarction (AMI). Design: CFR was measured using an intracoronary Doppler wire in 102 patients with AMI at baseline and at 8 months. Changes in the absolute number of circulating angiogenic cells were measured at baseline, 1 day, 5 days and at 8 months. Stented patients were randomly assigned to either low-dose atorvastatin 10 mg (ATOR10, n=52) or moderate-dose atorvastatin 40 mg (ATOR40, n=50). Setting: University Hospital. Results: CFR increased significantly in both groups during the 8-month follow-up. The 8-month increases from baseline in CFR were significantly greater in the ATOR40 group than in the ATOR10 group (0.99±0.69 vs 0.55±0.47, p=0.017, respectively). The serial increases in the absolute number of CD34+ and CXCR4+ cells were significantly greater in the ATOR40 group, especially at 24 h after the procedure (two-way repeated-measures analysis of variance: p=0.046 and p=0.022, respectively). Decreases from baseline for interleukin 6 (-2.94±3.31 vs -1.52±2.82 pg/ml), tumour necrosis factor α (-1.31±2.96 vs -0.01±1.29 pg/ml), soluble intercellular adhesion molecule-1 (-71±95 vs 37±83 ng/ml) and soluble vascular cell adhesion molecule-1 (-51±364 vs 190±204 ng/ml) were significantly greater in the ATOR40 group. Conclusions: The recovery of microvascular integrity after acute ischaemic injury in the ATOR40 group was expedited by greater circulating angiogenic cell mobilisations such as CD34+ and CXCR4+ cells, together with greater decreases in inflammatory cytokines and low-density lipoprotein- cholesterol concentrations. Registration number: http://ClinicalTrials.gov number, NCT00536887.

AB - Objective: To compare the effects of atorvastatin 10 mg versus 40 mg in circulating angiogenic cell mobilisations and in restoring coronary flow reserve (CFR) during the 8-month follow-up in patients with a first acute myocardial infarction (AMI). Design: CFR was measured using an intracoronary Doppler wire in 102 patients with AMI at baseline and at 8 months. Changes in the absolute number of circulating angiogenic cells were measured at baseline, 1 day, 5 days and at 8 months. Stented patients were randomly assigned to either low-dose atorvastatin 10 mg (ATOR10, n=52) or moderate-dose atorvastatin 40 mg (ATOR40, n=50). Setting: University Hospital. Results: CFR increased significantly in both groups during the 8-month follow-up. The 8-month increases from baseline in CFR were significantly greater in the ATOR40 group than in the ATOR10 group (0.99±0.69 vs 0.55±0.47, p=0.017, respectively). The serial increases in the absolute number of CD34+ and CXCR4+ cells were significantly greater in the ATOR40 group, especially at 24 h after the procedure (two-way repeated-measures analysis of variance: p=0.046 and p=0.022, respectively). Decreases from baseline for interleukin 6 (-2.94±3.31 vs -1.52±2.82 pg/ml), tumour necrosis factor α (-1.31±2.96 vs -0.01±1.29 pg/ml), soluble intercellular adhesion molecule-1 (-71±95 vs 37±83 ng/ml) and soluble vascular cell adhesion molecule-1 (-51±364 vs 190±204 ng/ml) were significantly greater in the ATOR40 group. Conclusions: The recovery of microvascular integrity after acute ischaemic injury in the ATOR40 group was expedited by greater circulating angiogenic cell mobilisations such as CD34+ and CXCR4+ cells, together with greater decreases in inflammatory cytokines and low-density lipoprotein- cholesterol concentrations. Registration number: http://ClinicalTrials.gov number, NCT00536887.

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