Low-fluence Q-switched Nd:YAG laser for the treatment of melasma in Asian patients

Jae Eun Choi, Dong Won Lee, Soo-Hong Seo, Hyo Hyun Ahn, Young Chul Kye

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2 Citations (Scopus)

Abstract

Background: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia. Objective: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. Methods: Data of patients with melasma treated with low-fluence QSNY in the department of dermatology at the Korea University Anam Hospital were reviewed retrospectively. A 1064-nm QSNY with 8 mm spot size and fluence of 1.2-2.0 J/cm2 at 10 Hz was used. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment (PGA). Results: A total of 40 Korean patients with Fitzpatrick skin type III to IV were included. Patients were treated for a median of 10 sessions at a median of 1-week intervals. The mean mMASI score decreased by 54.23% from a baseline of 3.19 ± 2.64 to 1.46 ± 1.06 after treatment. On PGA, 1 out of 40 patients (2.5%) showed excellent improvement, 14 (35%) good, 15 (37.5%) fair, 6 (15%) poor, and 4 (10%) no improvement. However, two patients showed mottled hypopigmentation and rebound hyperpigmentation. Conclusion: Low-fluence 1064-nm QSNY appears to be a safe and effective treatment for Asian patients with melasma.

Original languageEnglish
JournalJournal of Cosmetic Dermatology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Melanosis
Solid-State Lasers
Therapeutics
Hypopigmentation
Physicians
Hyperpigmentation
Korea
Dermatology
Safety
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{1caede6cdce44fe8b8b26456a340626c,
title = "Low-fluence Q-switched Nd:YAG laser for the treatment of melasma in Asian patients",
abstract = "Background: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia. Objective: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. Methods: Data of patients with melasma treated with low-fluence QSNY in the department of dermatology at the Korea University Anam Hospital were reviewed retrospectively. A 1064-nm QSNY with 8 mm spot size and fluence of 1.2-2.0 J/cm2 at 10 Hz was used. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment (PGA). Results: A total of 40 Korean patients with Fitzpatrick skin type III to IV were included. Patients were treated for a median of 10 sessions at a median of 1-week intervals. The mean mMASI score decreased by 54.23{\%} from a baseline of 3.19 ± 2.64 to 1.46 ± 1.06 after treatment. On PGA, 1 out of 40 patients (2.5{\%}) showed excellent improvement, 14 (35{\%}) good, 15 (37.5{\%}) fair, 6 (15{\%}) poor, and 4 (10{\%}) no improvement. However, two patients showed mottled hypopigmentation and rebound hyperpigmentation. Conclusion: Low-fluence 1064-nm QSNY appears to be a safe and effective treatment for Asian patients with melasma.",
author = "Choi, {Jae Eun} and Lee, {Dong Won} and Soo-Hong Seo and Ahn, {Hyo Hyun} and Kye, {Young Chul}",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/jocd.12760",
language = "English",
journal = "Journal of Cosmetic Dermatology",
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TY - JOUR

T1 - Low-fluence Q-switched Nd:YAG laser for the treatment of melasma in Asian patients

AU - Choi, Jae Eun

AU - Lee, Dong Won

AU - Seo, Soo-Hong

AU - Ahn, Hyo Hyun

AU - Kye, Young Chul

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia. Objective: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. Methods: Data of patients with melasma treated with low-fluence QSNY in the department of dermatology at the Korea University Anam Hospital were reviewed retrospectively. A 1064-nm QSNY with 8 mm spot size and fluence of 1.2-2.0 J/cm2 at 10 Hz was used. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment (PGA). Results: A total of 40 Korean patients with Fitzpatrick skin type III to IV were included. Patients were treated for a median of 10 sessions at a median of 1-week intervals. The mean mMASI score decreased by 54.23% from a baseline of 3.19 ± 2.64 to 1.46 ± 1.06 after treatment. On PGA, 1 out of 40 patients (2.5%) showed excellent improvement, 14 (35%) good, 15 (37.5%) fair, 6 (15%) poor, and 4 (10%) no improvement. However, two patients showed mottled hypopigmentation and rebound hyperpigmentation. Conclusion: Low-fluence 1064-nm QSNY appears to be a safe and effective treatment for Asian patients with melasma.

AB - Background: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia. Objective: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. Methods: Data of patients with melasma treated with low-fluence QSNY in the department of dermatology at the Korea University Anam Hospital were reviewed retrospectively. A 1064-nm QSNY with 8 mm spot size and fluence of 1.2-2.0 J/cm2 at 10 Hz was used. The results were evaluated using the modified Melasma Area and Severity Index (mMASI) score and the physician's global assessment (PGA). Results: A total of 40 Korean patients with Fitzpatrick skin type III to IV were included. Patients were treated for a median of 10 sessions at a median of 1-week intervals. The mean mMASI score decreased by 54.23% from a baseline of 3.19 ± 2.64 to 1.46 ± 1.06 after treatment. On PGA, 1 out of 40 patients (2.5%) showed excellent improvement, 14 (35%) good, 15 (37.5%) fair, 6 (15%) poor, and 4 (10%) no improvement. However, two patients showed mottled hypopigmentation and rebound hyperpigmentation. Conclusion: Low-fluence 1064-nm QSNY appears to be a safe and effective treatment for Asian patients with melasma.

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