Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: A single center experience

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Abstract

Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20–30 ng/mL), or sufficiency (≥30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6±8.5 ng/mL vs. 28.0±12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalAnnals of Pediatric Endocrinology and Metabolism
Volume23
Issue number1
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Type 1 Diabetes Mellitus
Vitamin D Deficiency
Vitamin D
25-hydroxyvitamin D
C-Peptide
Serum
Diabetes Mellitus
Body Mass Index
Logistic Models
Regression Analysis
Insulin

Keywords

  • Case-control studies
  • Child
  • Diabetes mellitus
  • Type 1
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: A single center experience",
abstract = "Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20–30 ng/mL), or sufficiency (≥30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6±8.5 ng/mL vs. 28.0±12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48{\%} vs. 26{\%}, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.",
keywords = "Case-control studies, Child, Diabetes mellitus, Type 1, Vitamin D deficiency",
author = "Bae, {Ki Nam} and Hyo-Kyoung Nam and Young-Jun Rhie and Dae-Jin Song and Lee, {Kee Hyoung}",
year = "2018",
month = "3",
day = "1",
doi = "10.6065/apem.2018.23.1.21",
language = "English",
volume = "23",
pages = "21--27",
journal = "Annals of Pediatric Endocrinology and Metabolism",
issn = "2287-1012",
publisher = "Korean society of pediatric endocrinology",
number = "1",

}

TY - JOUR

T1 - Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus

T2 - A single center experience

AU - Bae, Ki Nam

AU - Nam, Hyo-Kyoung

AU - Rhie, Young-Jun

AU - Song, Dae-Jin

AU - Lee, Kee Hyoung

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20–30 ng/mL), or sufficiency (≥30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6±8.5 ng/mL vs. 28.0±12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.

AB - Purpose: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. Methods: Type 1 DM cases (n=85) and healthy controls (n=518) aged <20 years were included and grouped into 3 categories according to vitamin D level: deficiency (<20 ng/mL), insufficiency (20–30 ng/mL), or sufficiency (≥30 ng/mL). Results: The mean serum vitamin D level was significantly lower (21.6±8.5 ng/mL vs. 28.0±12.0 ng/mL, P<0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P<0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. Conclusion: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.

KW - Case-control studies

KW - Child

KW - Diabetes mellitus

KW - Type 1

KW - Vitamin D deficiency

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U2 - 10.6065/apem.2018.23.1.21

DO - 10.6065/apem.2018.23.1.21

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JO - Annals of Pediatric Endocrinology and Metabolism

JF - Annals of Pediatric Endocrinology and Metabolism

SN - 2287-1012

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