Low-rank representation for multi-center autism spectrum disorder identification

Mingliang Wang, Daoqiang Zhang, Jiashuang Huang, Dinggang Shen, Mingxia Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Citations (Scopus)


Effective utilization of multi-center data for autism spectrum disorder (ASD) diagnosis recently has attracted increasing attention, since a large number of subjects from multiple centers are beneficial for investigating the pathological changes of ASD. To better utilize the multi-center data, various machine learning methods have been proposed. However, most previous studies do not consider the problem of data heterogeneity (e.g., caused by different scanning parameters and subject populations) among multi-center datasets, which may degrade the diagnosis performance based on multi-center data. To address this issue, we propose a multi-center low-rank representation learning (MCLRR) method for ASD diagnosis, to seek a good representation of subjects from different centers. Specifically, we first choose one center as the target domain and the remaining centers as source domains. We then learn a domain-specific projection for each source domain to transform them into an intermediate representation space. To further suppress the heterogeneity among multiple centers, we disassemble the learned projection matrices into a shared part and a sparse unique part. With the shared matrix, we can project target domain to the common latent space, and linearly represent the source domain datasets using data in the transformed target domain. Based on the learned low-rank representation, we employ the k-nearest neighbor (KNN) algorithm to perform disease classification. Our method has been evaluated on the ABIDE database, and the superior classification results demonstrate the effectiveness of our proposed method as compared to other methods.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
EditorsJulia A. Schnabel, Christos Davatzikos, Carlos Alberola-López, Gabor Fichtinger, Alejandro F. Frangi
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783030009274
Publication statusPublished - 2018
Event21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain
Duration: 2018 Sept 162018 Sept 20

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11070 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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