Low resolution electromagnetic tomography analysis of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis

Eun Mi Lee, Young Min Shon, Ki Young Jung, Sang Ahm Lee, Myung Kul Yum, II Keun Lee, Ji Hyun Kim, Ki Jong Park, Oh Young Kwon, Joong Koo Kang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To investigate the difference in the spatial distribution of scalp initial ictal discharge (IID) patterns in mesial temporal lobe epilepsy with hippocampal sclerosis (HS-MTLE). Methods: Scalp ictal EEG data in 22 seizure-free patients after temporal lobectomy with amygdalo-hippocampectomy were classified as follows: a regular 5-9 Hz rhythm with a restricted temporal/subtemporal distribution (type 1, 11 patients), or an irregular 2-5 Hz rhythm with a widespread fronto-temporal distribution (type 2, 11 patients). EEG data were fragmented into segments of 1.28 s, both at ictal onset and at baseline. The LORETA solution of three frequency bands was compared between ictal and baseline using statistical non-parametric mapping (p < 0.01). Results: The LORETA solution of 5-9 Hz in type 2 had wider cortical activity in the ipsilateral fronto-temporal area, compared to type 1 with activation of the ipsilateral focal mesial and lateral temporal regions. The LORETA solution of 10-13 Hz in both types showed increased activity in the fronto-temporal area, which was wider in type 2 than type 1. Increased cortical activity of <5 Hz was not observed in type 1, whereas increased cortical activity was observed in the bilateral anterior frontal area in type 2. Conclusions: The cortical source distribution in HS-MTLE may depend on scalp IID frequency. The neural generators of 5-13 Hz may be important for the formation of the ictal onset zone in both ictal patterns. Significance: Spatial distributions in HS-MTLE patients differ with scalp IID frequency.

Original languageEnglish
Pages (from-to)1797-1805
Number of pages9
JournalClinical Neurophysiology
Volume120
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Temporal Lobe Epilepsy
Electromagnetic Phenomena
Sclerosis
Electroencephalography
Stroke
Tomography
Scalp
Temporal Lobe
Seizures

Keywords

  • Hippocampal sclerosis
  • Initial ictal discharge
  • LORETA
  • Mesial temporal lobe epilepsy
  • Source localization

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Low resolution electromagnetic tomography analysis of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis. / Lee, Eun Mi; Shon, Young Min; Jung, Ki Young; Lee, Sang Ahm; Yum, Myung Kul; Lee, II Keun; Kim, Ji Hyun; Park, Ki Jong; Kwon, Oh Young; Kang, Joong Koo.

In: Clinical Neurophysiology, Vol. 120, No. 10, 01.10.2009, p. 1797-1805.

Research output: Contribution to journalArticle

Lee, Eun Mi ; Shon, Young Min ; Jung, Ki Young ; Lee, Sang Ahm ; Yum, Myung Kul ; Lee, II Keun ; Kim, Ji Hyun ; Park, Ki Jong ; Kwon, Oh Young ; Kang, Joong Koo. / Low resolution electromagnetic tomography analysis of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis. In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 10. pp. 1797-1805.
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abstract = "Objective: To investigate the difference in the spatial distribution of scalp initial ictal discharge (IID) patterns in mesial temporal lobe epilepsy with hippocampal sclerosis (HS-MTLE). Methods: Scalp ictal EEG data in 22 seizure-free patients after temporal lobectomy with amygdalo-hippocampectomy were classified as follows: a regular 5-9 Hz rhythm with a restricted temporal/subtemporal distribution (type 1, 11 patients), or an irregular 2-5 Hz rhythm with a widespread fronto-temporal distribution (type 2, 11 patients). EEG data were fragmented into segments of 1.28 s, both at ictal onset and at baseline. The LORETA solution of three frequency bands was compared between ictal and baseline using statistical non-parametric mapping (p < 0.01). Results: The LORETA solution of 5-9 Hz in type 2 had wider cortical activity in the ipsilateral fronto-temporal area, compared to type 1 with activation of the ipsilateral focal mesial and lateral temporal regions. The LORETA solution of 10-13 Hz in both types showed increased activity in the fronto-temporal area, which was wider in type 2 than type 1. Increased cortical activity of <5 Hz was not observed in type 1, whereas increased cortical activity was observed in the bilateral anterior frontal area in type 2. Conclusions: The cortical source distribution in HS-MTLE may depend on scalp IID frequency. The neural generators of 5-13 Hz may be important for the formation of the ictal onset zone in both ictal patterns. Significance: Spatial distributions in HS-MTLE patients differ with scalp IID frequency.",
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AU - Shon, Young Min

AU - Jung, Ki Young

AU - Lee, Sang Ahm

AU - Yum, Myung Kul

AU - Lee, II Keun

AU - Kim, Ji Hyun

AU - Park, Ki Jong

AU - Kwon, Oh Young

AU - Kang, Joong Koo

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N2 - Objective: To investigate the difference in the spatial distribution of scalp initial ictal discharge (IID) patterns in mesial temporal lobe epilepsy with hippocampal sclerosis (HS-MTLE). Methods: Scalp ictal EEG data in 22 seizure-free patients after temporal lobectomy with amygdalo-hippocampectomy were classified as follows: a regular 5-9 Hz rhythm with a restricted temporal/subtemporal distribution (type 1, 11 patients), or an irregular 2-5 Hz rhythm with a widespread fronto-temporal distribution (type 2, 11 patients). EEG data were fragmented into segments of 1.28 s, both at ictal onset and at baseline. The LORETA solution of three frequency bands was compared between ictal and baseline using statistical non-parametric mapping (p < 0.01). Results: The LORETA solution of 5-9 Hz in type 2 had wider cortical activity in the ipsilateral fronto-temporal area, compared to type 1 with activation of the ipsilateral focal mesial and lateral temporal regions. The LORETA solution of 10-13 Hz in both types showed increased activity in the fronto-temporal area, which was wider in type 2 than type 1. Increased cortical activity of <5 Hz was not observed in type 1, whereas increased cortical activity was observed in the bilateral anterior frontal area in type 2. Conclusions: The cortical source distribution in HS-MTLE may depend on scalp IID frequency. The neural generators of 5-13 Hz may be important for the formation of the ictal onset zone in both ictal patterns. Significance: Spatial distributions in HS-MTLE patients differ with scalp IID frequency.

AB - Objective: To investigate the difference in the spatial distribution of scalp initial ictal discharge (IID) patterns in mesial temporal lobe epilepsy with hippocampal sclerosis (HS-MTLE). Methods: Scalp ictal EEG data in 22 seizure-free patients after temporal lobectomy with amygdalo-hippocampectomy were classified as follows: a regular 5-9 Hz rhythm with a restricted temporal/subtemporal distribution (type 1, 11 patients), or an irregular 2-5 Hz rhythm with a widespread fronto-temporal distribution (type 2, 11 patients). EEG data were fragmented into segments of 1.28 s, both at ictal onset and at baseline. The LORETA solution of three frequency bands was compared between ictal and baseline using statistical non-parametric mapping (p < 0.01). Results: The LORETA solution of 5-9 Hz in type 2 had wider cortical activity in the ipsilateral fronto-temporal area, compared to type 1 with activation of the ipsilateral focal mesial and lateral temporal regions. The LORETA solution of 10-13 Hz in both types showed increased activity in the fronto-temporal area, which was wider in type 2 than type 1. Increased cortical activity of <5 Hz was not observed in type 1, whereas increased cortical activity was observed in the bilateral anterior frontal area in type 2. Conclusions: The cortical source distribution in HS-MTLE may depend on scalp IID frequency. The neural generators of 5-13 Hz may be important for the formation of the ictal onset zone in both ictal patterns. Significance: Spatial distributions in HS-MTLE patients differ with scalp IID frequency.

KW - Hippocampal sclerosis

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KW - LORETA

KW - Mesial temporal lobe epilepsy

KW - Source localization

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