Low temperature flow lithography

H. Lee, Y. H. Roh, H. U. Kim, Ki Wan Bong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Flow lithography (FL) is a microfluidic technique distinguished for its ability to produce hydrogel microparticles of various geometrical and chemical designs. While FL is typically performed in room temperature, this paper reports a new technique called low temperature flow lithography that uses low synthesis temperature to increase the degree of polymerization of microparticles without compromising other aspects of flow lithography. We suggest that decreased oxygen diffusivity in low temperature is responsible for the increase in polymerization. Microparticles that exhibit a higher degree of polymerization display a more developed polymer network, ultimately resulting in a more defined morphology, higher incorporation of materials of interest, and improved functional performance. This work demonstrates the increase in the degree of polymerization by examining the temperature effect on both the physical and chemical structures of particles. We show applications of this technique in synthesizing thin microparticles and enhancing microparticle-based detection of microRNA. Low temperature FL offers a simple and easy method of improving the degree of polymerization, which can be implemented in a wide range of FL applications.

Original languageEnglish
Article number054105
JournalBiomicrofluidics
Volume12
Issue number5
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Lithography
microparticles
Polymerization
lithography
polymerization
Temperature
Microfluidics
Hydrogel
MicroRNAs
Hydrogels
Thermal effects
diffusivity
temperature effects
Polymers
Oxygen
polymers
room temperature
oxygen
synthesis
temperature

ASJC Scopus subject areas

  • Molecular Biology
  • Materials Science(all)
  • Genetics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Low temperature flow lithography. / Lee, H.; Roh, Y. H.; Kim, H. U.; Bong, Ki Wan.

In: Biomicrofluidics, Vol. 12, No. 5, 054105, 01.09.2018.

Research output: Contribution to journalArticle

Lee, H. ; Roh, Y. H. ; Kim, H. U. ; Bong, Ki Wan. / Low temperature flow lithography. In: Biomicrofluidics. 2018 ; Vol. 12, No. 5.
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