Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Hwa Young Lee, Jin Woo Kim, Sang Haak Lee, Hyoung Kyu Yoon, Jae Jeong Shim, Jeong Woong Park, Jae Hyung Lee, Kwang Ha Yoo, Ki Suck Jung, Chin Kook Rhee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DLCO); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms. A total of 51% of patients had high DLCO without CB symptoms [CB (-) high DLCO], 24.9% had CB symptoms only [CB (+) high DLCO], 14.2% had low DLCO only [CB (-) low DLCO], and 10.2% had both low DLCO and CB [CB (+) low DLCO]. Patients with CB (+) low DLCO showed a significantly lower postbronchodilator (BD) forced expiratory volume for 1 second (FEV1) and more severe dyspnea than patients with CB (-) high DLCO. On multivariate analysis, the risk of acute exacerbation was two times higher [odds ratio (OR) 2.06; 95% confidence interval (CI): 1.18-3.62; P=0.01] in the CB (+) low DLCO group than in the CB (-) high DLCO group. Conclusions: In this COPD cohort, patients showed distinct clinical characteristics and outcomes according to the presence of CB and degree of DLCO. CB and low DLCO were associated with the risk of acute exacerbation.

Original languageEnglish
Pages (from-to)1274-1282
Number of pages9
JournalJournal of Thoracic Disease
Volume8
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

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Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Lung Volume Measurements
Respiratory Function Tests
Emphysema
Forced Expiratory Volume
Carbon Monoxide
Korea
Dyspnea

Keywords

  • Acute exacerbation
  • Chronic bronchitis (CB)
  • Chronic obstructive lung disease (COPD)
  • Diffusing capacity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease. / Lee, Hwa Young; Kim, Jin Woo; Lee, Sang Haak; Yoon, Hyoung Kyu; Shim, Jae Jeong; Park, Jeong Woong; Lee, Jae Hyung; Yoo, Kwang Ha; Jung, Ki Suck; Rhee, Chin Kook.

In: Journal of Thoracic Disease, Vol. 8, No. 6, 01.06.2016, p. 1274-1282.

Research output: Contribution to journalArticle

Lee, Hwa Young ; Kim, Jin Woo ; Lee, Sang Haak ; Yoon, Hyoung Kyu ; Shim, Jae Jeong ; Park, Jeong Woong ; Lee, Jae Hyung ; Yoo, Kwang Ha ; Jung, Ki Suck ; Rhee, Chin Kook. / Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease. In: Journal of Thoracic Disease. 2016 ; Vol. 8, No. 6. pp. 1274-1282.
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abstract = "Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DLCO); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1{\%}) had CB symptoms. A total of 51{\%} of patients had high DLCO without CB symptoms [CB (-) high DLCO], 24.9{\%} had CB symptoms only [CB (+) high DLCO], 14.2{\%} had low DLCO only [CB (-) low DLCO], and 10.2{\%} had both low DLCO and CB [CB (+) low DLCO]. Patients with CB (+) low DLCO showed a significantly lower postbronchodilator (BD) forced expiratory volume for 1 second (FEV1) and more severe dyspnea than patients with CB (-) high DLCO. On multivariate analysis, the risk of acute exacerbation was two times higher [odds ratio (OR) 2.06; 95{\%} confidence interval (CI): 1.18-3.62; P=0.01] in the CB (+) low DLCO group than in the CB (-) high DLCO group. Conclusions: In this COPD cohort, patients showed distinct clinical characteristics and outcomes according to the presence of CB and degree of DLCO. CB and low DLCO were associated with the risk of acute exacerbation.",
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T1 - Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

AU - Lee, Hwa Young

AU - Kim, Jin Woo

AU - Lee, Sang Haak

AU - Yoon, Hyoung Kyu

AU - Shim, Jae Jeong

AU - Park, Jeong Woong

AU - Lee, Jae Hyung

AU - Yoo, Kwang Ha

AU - Jung, Ki Suck

AU - Rhee, Chin Kook

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DLCO); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms. A total of 51% of patients had high DLCO without CB symptoms [CB (-) high DLCO], 24.9% had CB symptoms only [CB (+) high DLCO], 14.2% had low DLCO only [CB (-) low DLCO], and 10.2% had both low DLCO and CB [CB (+) low DLCO]. Patients with CB (+) low DLCO showed a significantly lower postbronchodilator (BD) forced expiratory volume for 1 second (FEV1) and more severe dyspnea than patients with CB (-) high DLCO. On multivariate analysis, the risk of acute exacerbation was two times higher [odds ratio (OR) 2.06; 95% confidence interval (CI): 1.18-3.62; P=0.01] in the CB (+) low DLCO group than in the CB (-) high DLCO group. Conclusions: In this COPD cohort, patients showed distinct clinical characteristics and outcomes according to the presence of CB and degree of DLCO. CB and low DLCO were associated with the risk of acute exacerbation.

AB - Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DLCO); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms. A total of 51% of patients had high DLCO without CB symptoms [CB (-) high DLCO], 24.9% had CB symptoms only [CB (+) high DLCO], 14.2% had low DLCO only [CB (-) low DLCO], and 10.2% had both low DLCO and CB [CB (+) low DLCO]. Patients with CB (+) low DLCO showed a significantly lower postbronchodilator (BD) forced expiratory volume for 1 second (FEV1) and more severe dyspnea than patients with CB (-) high DLCO. On multivariate analysis, the risk of acute exacerbation was two times higher [odds ratio (OR) 2.06; 95% confidence interval (CI): 1.18-3.62; P=0.01] in the CB (+) low DLCO group than in the CB (-) high DLCO group. Conclusions: In this COPD cohort, patients showed distinct clinical characteristics and outcomes according to the presence of CB and degree of DLCO. CB and low DLCO were associated with the risk of acute exacerbation.

KW - Acute exacerbation

KW - Chronic bronchitis (CB)

KW - Chronic obstructive lung disease (COPD)

KW - Diffusing capacity

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