LTD induction suppresses LTP-induced hippocampal adult neurogenesis

Sung Kun Chun, Woong Sun, Min Whan Jung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.

Original languageEnglish
Pages (from-to)1279-1283
Number of pages5
JournalNeuroReport
Volume20
Issue number14
DOIs
Publication statusPublished - 2009 Sep 1

Fingerprint

Long-Term Potentiation
Neurogenesis
Dentate Gyrus
Stem Cells
Cell Proliferation
Afferent Pathways
Neuronal Plasticity
Brain

Keywords

  • Adult neurogenesis
  • Cell proliferation
  • Hippocampus
  • LTD and LTP
  • Progenitor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

LTD induction suppresses LTP-induced hippocampal adult neurogenesis. / Chun, Sung Kun; Sun, Woong; Jung, Min Whan.

In: NeuroReport, Vol. 20, No. 14, 01.09.2009, p. 1279-1283.

Research output: Contribution to journalArticle

Chun, Sung Kun ; Sun, Woong ; Jung, Min Whan. / LTD induction suppresses LTP-induced hippocampal adult neurogenesis. In: NeuroReport. 2009 ; Vol. 20, No. 14. pp. 1279-1283.
@article{f7ec4980a03748c397936d0a5784fd7f,
title = "LTD induction suppresses LTP-induced hippocampal adult neurogenesis",
abstract = "Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.",
keywords = "Adult neurogenesis, Cell proliferation, Hippocampus, LTD and LTP, Progenitor",
author = "Chun, {Sung Kun} and Woong Sun and Jung, {Min Whan}",
year = "2009",
month = "9",
day = "1",
doi = "10.1097/WNR.0b013e3283303794",
language = "English",
volume = "20",
pages = "1279--1283",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

TY - JOUR

T1 - LTD induction suppresses LTP-induced hippocampal adult neurogenesis

AU - Chun, Sung Kun

AU - Sun, Woong

AU - Jung, Min Whan

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.

AB - Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.

KW - Adult neurogenesis

KW - Cell proliferation

KW - Hippocampus

KW - LTD and LTP

KW - Progenitor

UR - http://www.scopus.com/inward/record.url?scp=70349145437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349145437&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e3283303794

DO - 10.1097/WNR.0b013e3283303794

M3 - Article

C2 - 19633582

AN - SCOPUS:70349145437

VL - 20

SP - 1279

EP - 1283

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 14

ER -