Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Soo Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The luminescence and magnetic resonance imaging (MRI) and photodynamic therapy (PDT) using lanthanide-doped upconverting nanoparticles (UCNPs) is reported. With the aim to induce a therapeutic effect, a photosensitizer, chlorin e6 (Ce6), was conjugated to UCNPs. Owing to the enhanced permeability and retention effect, UCNPs combined with a photosensitizer, chlorin e6 (UCNP-Ce6) could be readily accumulated at the tumors, which could be clearly observed not only in the upconversion luminescence image but also in the MRI image. Using the energy transfer from UCNPs to Ce6, cytotoxic singlet oxygen could be generated. An in vivo PDT effect by systemic administration of UCNP-Ce6 was demonstrated under 980-nm irradiation. These results indicate that UCNP-Ce6 can be used not only as dual-modal imaging probes for accurate diagnosis but also as photodynamic therapy agent for efficient therapy.

Original languageEnglish
Title of host publicationNanosystems in Engineering and Medicine
DOIs
Publication statusPublished - 2012
EventNanosystems in Engineering and Medicine - Incheon, Korea, Republic of
Duration: 2012 Sep 102012 Sep 12

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8548
ISSN (Print)1605-7422

Other

OtherNanosystems in Engineering and Medicine
CountryKorea, Republic of
CityIncheon
Period12/9/1012/9/12

Keywords

  • Energy transfer
  • lanthanide
  • luminescence
  • magnetic resonance imaging
  • nanoparticles
  • photodynamic therapy
  • upconversion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., Yoon, S. Y., Suh, Y. D., Lee, S. H., & Hyeon, T. (2012). Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. In Nanosystems in Engineering and Medicine [85482H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8548). https://doi.org/10.1117/12.999411