Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Soo-Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The luminescence and magnetic resonance imaging (MRI) and photodynamic therapy (PDT) using lanthanide-doped upconverting nanoparticles (UCNPs) is reported. With the aim to induce a therapeutic effect, a photosensitizer, chlorin e6 (Ce6), was conjugated to UCNPs. Owing to the enhanced permeability and retention effect, UCNPs combined with a photosensitizer, chlorin e6 (UCNP-Ce6) could be readily accumulated at the tumors, which could be clearly observed not only in the upconversion luminescence image but also in the MRI image. Using the energy transfer from UCNPs to Ce6, cytotoxic singlet oxygen could be generated. An in vivo PDT effect by systemic administration of UCNP-Ce6 was demonstrated under 980-nm irradiation. These results indicate that UCNP-Ce6 can be used not only as dual-modal imaging probes for accurate diagnosis but also as photodynamic therapy agent for efficient therapy.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8548
DOIs
Publication statusPublished - 2012 Dec 1
EventNanosystems in Engineering and Medicine - Incheon, Korea, Republic of
Duration: 2012 Sep 102012 Sep 12

Other

OtherNanosystems in Engineering and Medicine
CountryKorea, Republic of
CityIncheon
Period12/9/1012/9/12

Fingerprint

Photodynamic therapy
Photochemotherapy
Magnetic resonance
Luminescence
Nanoparticles
magnetic resonance
therapy
Magnetic Resonance Imaging
luminescence
Imaging techniques
nanoparticles
Photosensitizing Agents
Photosensitizers
Lanthanoid Series Elements
Singlet Oxygen
Energy Transfer
Therapeutic Uses
Rare earth elements
Energy transfer
Tumors

Keywords

  • Energy transfer
  • lanthanide
  • luminescence
  • magnetic resonance imaging
  • nanoparticles
  • photodynamic therapy
  • upconversion

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., ... Hyeon, T. (2012). Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8548). [85482H] https://doi.org/10.1117/12.999411

Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. / Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8548 2012. 85482H.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Park, YI, Kim, HM, Kim, JH, Moon, KC, Yoo, B, Lee, KT, Yoon, S-Y, Suh, YD, Lee, SH & Hyeon, T 2012, Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8548, 85482H, Nanosystems in Engineering and Medicine, Incheon, Korea, Republic of, 12/9/10. https://doi.org/10.1117/12.999411
Park YI, Kim HM, Kim JH, Moon KC, Yoo B, Lee KT et al. Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8548. 2012. 85482H https://doi.org/10.1117/12.999411
Park, Yong Il ; Kim, Hyung Min ; Kim, Jeong Hyun ; Moon, Kyung Chul ; Yoo, Byeongjun ; Lee, Kang Taek ; Yoon, Soo-Young ; Suh, Yung Doug ; Lee, Sung Ho ; Hyeon, Taeghwan. / Luminescence/magnetic resonance imaging and photodynamic therapy based on upconverting nanoparticles. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8548 2012.
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