Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis

A Korean Lung Cancer Registry Study

Kwang Ho In, Yong Soo Kwon, In Jae Oh, Kyu Sik Kim, Maan Hong Jung, Kwan Ho Lee, Sun Young Kim, Jeong Seon Ryu, Sung Yong Lee, Eun Taik Jeong, Sang Yeub Lee, Ho Kee Yum, Chang Geol Lee, Woo Sung Kim, Jae Ill Zo, Hojoong Kim, Young Whan Kim, Se Kyu Kim, Jae Cheol Lee, Young Chul Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose and methods: The outcomes of lung cancer patients who were asymptomatic at diagnosis have never been reported as part of a large-scale study. A national survey of lung cancer in South Korea registered a total of 8788 patients diagnosed in 2005. We report the results herein, with an emphasis on the prognosis of the asymptomatic lung cancer patients. Results: Adenocarcinoma was the most frequent (36.1%) histopathologic type, followed by squamous cell carcinoma (32.1%), large cell carcinoma (1.5%), and small cell carcinoma (13.5%). In most cases, lung cancer was detected with subjective symptoms, but 6.5% of cases had no symptoms indicative of lung cancer at the time of diagnosis. Compared to symptomatic patients, asymptomatic patients were younger, more often female, non-smokers, and more frequently presented with adenocarcinoma. Initial treatments were surgery (22.1%), radiation therapy (7.8%), chemo-radiation therapy (5.4%), and chemotherapy (38%), while 26.6% of patients were recorded to have supportive care only. Asymptomatic patients received surgery in 60.0% of cases, and they showed significantly longer survival times than symptomatic patients. Absence of symptoms at diagnosis significantly reduced the risk of death from non-small cell lung cancer, regardless of patient age, patient gender, stage at diagnosis, smoking history, or whether treatment was performed, but did not reduce the risk of death from small cell lung cancer. Conclusions: Adenocarcinoma has grown to be the leading histopathologic type of lung cancer in South Korea. Absence of symptom at diagnosis is a favorable prognostic factor for patients with non-small cell lung cancer.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalLung Cancer
Volume64
Issue number2
DOIs
Publication statusPublished - 2009 May 1

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Registries
Lung Neoplasms
Republic of Korea
Adenocarcinoma
Non-Small Cell Lung Carcinoma
Radiotherapy
Large Cell Carcinoma
Small Cell Carcinoma
Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Smoking
History
Drug Therapy
Survival
Therapeutics

Keywords

  • Epidemiology
  • Korea
  • Lung neoplasms
  • Registries
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis : A Korean Lung Cancer Registry Study. / In, Kwang Ho; Kwon, Yong Soo; Oh, In Jae; Kim, Kyu Sik; Jung, Maan Hong; Lee, Kwan Ho; Kim, Sun Young; Ryu, Jeong Seon; Lee, Sung Yong; Jeong, Eun Taik; Lee, Sang Yeub; Yum, Ho Kee; Lee, Chang Geol; Kim, Woo Sung; Zo, Jae Ill; Kim, Hojoong; Kim, Young Whan; Kim, Se Kyu; Lee, Jae Cheol; Kim, Young Chul.

In: Lung Cancer, Vol. 64, No. 2, 01.05.2009, p. 232-237.

Research output: Contribution to journalArticle

In, KH, Kwon, YS, Oh, IJ, Kim, KS, Jung, MH, Lee, KH, Kim, SY, Ryu, JS, Lee, SY, Jeong, ET, Lee, SY, Yum, HK, Lee, CG, Kim, WS, Zo, JI, Kim, H, Kim, YW, Kim, SK, Lee, JC & Kim, YC 2009, 'Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis: A Korean Lung Cancer Registry Study', Lung Cancer, vol. 64, no. 2, pp. 232-237. https://doi.org/10.1016/j.lungcan.2008.08.005
In, Kwang Ho ; Kwon, Yong Soo ; Oh, In Jae ; Kim, Kyu Sik ; Jung, Maan Hong ; Lee, Kwan Ho ; Kim, Sun Young ; Ryu, Jeong Seon ; Lee, Sung Yong ; Jeong, Eun Taik ; Lee, Sang Yeub ; Yum, Ho Kee ; Lee, Chang Geol ; Kim, Woo Sung ; Zo, Jae Ill ; Kim, Hojoong ; Kim, Young Whan ; Kim, Se Kyu ; Lee, Jae Cheol ; Kim, Young Chul. / Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis : A Korean Lung Cancer Registry Study. In: Lung Cancer. 2009 ; Vol. 64, No. 2. pp. 232-237.
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AU - Kwon, Yong Soo

AU - Oh, In Jae

AU - Kim, Kyu Sik

AU - Jung, Maan Hong

AU - Lee, Kwan Ho

AU - Kim, Sun Young

AU - Ryu, Jeong Seon

AU - Lee, Sung Yong

AU - Jeong, Eun Taik

AU - Lee, Sang Yeub

AU - Yum, Ho Kee

AU - Lee, Chang Geol

AU - Kim, Woo Sung

AU - Zo, Jae Ill

AU - Kim, Hojoong

AU - Kim, Young Whan

AU - Kim, Se Kyu

AU - Lee, Jae Cheol

AU - Kim, Young Chul

PY - 2009/5/1

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N2 - Purpose and methods: The outcomes of lung cancer patients who were asymptomatic at diagnosis have never been reported as part of a large-scale study. A national survey of lung cancer in South Korea registered a total of 8788 patients diagnosed in 2005. We report the results herein, with an emphasis on the prognosis of the asymptomatic lung cancer patients. Results: Adenocarcinoma was the most frequent (36.1%) histopathologic type, followed by squamous cell carcinoma (32.1%), large cell carcinoma (1.5%), and small cell carcinoma (13.5%). In most cases, lung cancer was detected with subjective symptoms, but 6.5% of cases had no symptoms indicative of lung cancer at the time of diagnosis. Compared to symptomatic patients, asymptomatic patients were younger, more often female, non-smokers, and more frequently presented with adenocarcinoma. Initial treatments were surgery (22.1%), radiation therapy (7.8%), chemo-radiation therapy (5.4%), and chemotherapy (38%), while 26.6% of patients were recorded to have supportive care only. Asymptomatic patients received surgery in 60.0% of cases, and they showed significantly longer survival times than symptomatic patients. Absence of symptoms at diagnosis significantly reduced the risk of death from non-small cell lung cancer, regardless of patient age, patient gender, stage at diagnosis, smoking history, or whether treatment was performed, but did not reduce the risk of death from small cell lung cancer. Conclusions: Adenocarcinoma has grown to be the leading histopathologic type of lung cancer in South Korea. Absence of symptom at diagnosis is a favorable prognostic factor for patients with non-small cell lung cancer.

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KW - Epidemiology

KW - Korea

KW - Lung neoplasms

KW - Registries

KW - Survival

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