Lung function decline rates according to gold group in patients with chronic obstructive pulmonary disease

Joohae Kim, Ho Il Yoon, Yeon Mok Oh, Seong Yong Lim, Ji Hyun Lee, Tae Hyung Kim, Sang Yeub Lee, Jin Hwa Lee, Sang Do Lee, Chang Hoon Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups A-D were introduced, the lung function changes according to group have been evaluated rarely. Objective: We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines. Methods: Patients with COPD included in the Korean Obstructive Lung Disease (KOLD) prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1), which was analyzed by random-slope and random-intercept mixed linear regression. Results: A total 175 participants were included. No significant postbronchodilator FEV1 decline was observed between the groups (-34.4±7.9 [group A]; -26.2±9.4 [group B]; -22.7±16.0 [group C]; and -24.0±8.7 mL/year [group D]) (P=0.79). The group with less symptoms (-32.3±7.2 vs -25.0±6.5 mL/year) (P=0.44) and the low risk group (-31.0±6.1 vs -23.6±7.7 mL/year) (P=0.44) at baseline showed a more rapid decline in the postbronchodilator FEV1, but the trends were not statistically significant. However, GOLD stages classified by FEV1 were significantly related to the annual lung function decline. Conclusion: There was no significant difference in lung function decline rates according to the GOLD groups. Prior classification using postbronchodilator FEV1 predicts decline in lung function better than does the new classification.

Original languageEnglish
Pages (from-to)1819-1827
Number of pages9
JournalInternational Journal of COPD
Volume10
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Forced Expiratory Volume
Gold
Chronic Obstructive Pulmonary Disease
Lung
Obstructive Lung Diseases
Spirometry
Linear Models
Prospective Studies
Guidelines

Keywords

  • Annual lung function decline
  • Chronic obstructive pulmonary disease
  • GOLD 2014

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Kim, J., Yoon, H. I., Oh, Y. M., Lim, S. Y., Lee, J. H., Kim, T. H., ... Lee, C. H. (2015). Lung function decline rates according to gold group in patients with chronic obstructive pulmonary disease. International Journal of COPD, 10(1), 1819-1827. https://doi.org/10.2147/COPD.S87766

Lung function decline rates according to gold group in patients with chronic obstructive pulmonary disease. / Kim, Joohae; Yoon, Ho Il; Oh, Yeon Mok; Lim, Seong Yong; Lee, Ji Hyun; Kim, Tae Hyung; Lee, Sang Yeub; Lee, Jin Hwa; Lee, Sang Do; Lee, Chang Hoon.

In: International Journal of COPD, Vol. 10, No. 1, 01.01.2015, p. 1819-1827.

Research output: Contribution to journalArticle

Kim, J, Yoon, HI, Oh, YM, Lim, SY, Lee, JH, Kim, TH, Lee, SY, Lee, JH, Lee, SD & Lee, CH 2015, 'Lung function decline rates according to gold group in patients with chronic obstructive pulmonary disease', International Journal of COPD, vol. 10, no. 1, pp. 1819-1827. https://doi.org/10.2147/COPD.S87766
Kim, Joohae ; Yoon, Ho Il ; Oh, Yeon Mok ; Lim, Seong Yong ; Lee, Ji Hyun ; Kim, Tae Hyung ; Lee, Sang Yeub ; Lee, Jin Hwa ; Lee, Sang Do ; Lee, Chang Hoon. / Lung function decline rates according to gold group in patients with chronic obstructive pulmonary disease. In: International Journal of COPD. 2015 ; Vol. 10, No. 1. pp. 1819-1827.
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