Lymph node metastasis in patients with frozen section analyses that are negative for tumors

Se Kyung Lee, Kyo Won Lee, Sangmin Kim, Min Young Choi, Jiyoung Kim, Jeonghui Lee, Seung Pil Jung, Jun Ho Choe, Jung Han Kim, Jee Soo Kim, Jeong Eon Lee, Jung Hyun Yang, Seok Jin Nam

Research output: Contribution to journalArticle

Abstract

Objectives: This study was designed to assess the necessity of delayed complete axillary lymph node dissection (cALND) for patients whose sentinel lymph nodes (SLNs) were negative for tumors on intraoperative frozen section analysis, but later proven positive on hematoxylin and eosin staining or immunohistochemistry. Methods: We identified 341 patients who underwent sentinel lymph node biopsy (SLNB) with cALND at the Samsung Medical Center between 1998 and 2008, and reviewed the clinicopathological records of women diagnosed with invasive carcinoma of the breast. Results: Of the 341 patients, 59 underwent delayed cALND due to negative results on frozen section. Only 1 patient had a non-SLNs metastasis in the group of delayed cALND. Delayed cALND was associated with higher rates of breast-conserving surgery, smaller primary tumor and metastasis size in SLNs, fewer metastatic lymph nodes and SLNs and a lower TNM stage. The detection of metastases of SLNs on frozen section and the number of metastatic SLNs were related to the detection of additional metastases of nonsentinel lymph nodes (NSLNs) in cALND. Conclusion: Our findings suggest that the lack of detection of metastases on frozen sections may be a predictive factor for nonmetastasis in NSLNs. cALND could therefore be omitted in such cases.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalOncology (Switzerland)
Volume83
Issue number1
DOIs
Publication statusPublished - 2012 Jul 1
Externally publishedYes

Fingerprint

Frozen Sections
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Sentinel Lymph Node Biopsy
Segmental Mastectomy
Hematoxylin
Eosine Yellowish-(YS)
Immunohistochemistry
Sentinel Lymph Node
Staining and Labeling
Breast Neoplasms

Keywords

  • Axillary lymph node dissection
  • Breast neoplasm
  • Frozen section analysis
  • Lymph node metastasis
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lee, S. K., Lee, K. W., Kim, S., Choi, M. Y., Kim, J., Lee, J., ... Nam, S. J. (2012). Lymph node metastasis in patients with frozen section analyses that are negative for tumors. Oncology (Switzerland), 83(1), 31-37. https://doi.org/10.1159/000336486

Lymph node metastasis in patients with frozen section analyses that are negative for tumors. / Lee, Se Kyung; Lee, Kyo Won; Kim, Sangmin; Choi, Min Young; Kim, Jiyoung; Lee, Jeonghui; Jung, Seung Pil; Choe, Jun Ho; Kim, Jung Han; Kim, Jee Soo; Lee, Jeong Eon; Yang, Jung Hyun; Nam, Seok Jin.

In: Oncology (Switzerland), Vol. 83, No. 1, 01.07.2012, p. 31-37.

Research output: Contribution to journalArticle

Lee, SK, Lee, KW, Kim, S, Choi, MY, Kim, J, Lee, J, Jung, SP, Choe, JH, Kim, JH, Kim, JS, Lee, JE, Yang, JH & Nam, SJ 2012, 'Lymph node metastasis in patients with frozen section analyses that are negative for tumors', Oncology (Switzerland), vol. 83, no. 1, pp. 31-37. https://doi.org/10.1159/000336486
Lee, Se Kyung ; Lee, Kyo Won ; Kim, Sangmin ; Choi, Min Young ; Kim, Jiyoung ; Lee, Jeonghui ; Jung, Seung Pil ; Choe, Jun Ho ; Kim, Jung Han ; Kim, Jee Soo ; Lee, Jeong Eon ; Yang, Jung Hyun ; Nam, Seok Jin. / Lymph node metastasis in patients with frozen section analyses that are negative for tumors. In: Oncology (Switzerland). 2012 ; Vol. 83, No. 1. pp. 31-37.
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