Lymph node status did not significantly improve the predictability of survival in patients with clinically early-stage endometrial cancer

HYo Sook Bae, Jong Min Lee, Jae Kwan Lee, Jae Weon Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim, Sokbom Kang

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to determine whether knowledge of lymph node status improves survival prediction in clinically early-stage endometrial cancer. Methods: The records of 661 patients with apparently uterine-confined disease were reviewed. The performance in predicting overall survival and cause-specific survival was compared between a multivariate prognostic model with nodal status and a model without nodal status by calculating Harrell concordance index. Results: Among 661 patients with clinically early-stage endometrial cancer, the lymph node metastasis rate was 8.3% (55/661). Lymph node metastasis independently associated with cause-specific survival only when no stratification according to adjuvant treatment was applied (P = 0.035). After stratification according to adjuvant radiotherapy, lymph node status marginally associated with cause-specific survival (P = 0.073), whereas myometrial invasion retained its strong association with cause-specific survival (P < 0.001). However, there was no significant difference in the performance of the survival model using only uterine factors and the model using lymph node status and uterine factors (concordance index, 0.77 vs 0.77, respectively; P = 0.798). Conclusions: Knowledge of lymph node status did not significantly improve the performance of survival prediction in apparently uterine-confined endometrial cancer, although it was independently associated with survival. In the patients with clinically early-stage endometrial cancer, the accuracy of the prediction of survival was comparable between risk grouping without lymph node status and that including lymph node status.

Original languageEnglish
Pages (from-to)1449-1454
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number8
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Endometrial cancer
  • Lymph node metastasis
  • Risk factor
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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