Lymphocytic hypophysitis in a patient with systemic lupus erythematosus

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Abstract

A case of lymphocytic hypophysitis in a patient with systemic lupus erythematosus is described. A 20-year-old woman was admitted to our hospital with generalized myalgia and facial rash in May 1998. The patient had a medical history, physical examination, and laboratory findings compatible with systemic lupus erythematosus (SLE). Headache and nausea had developed 3 months previously and worsened over the following months. Hormonal investigation showed hypopituitarism except for prolactin. A magnetic resonance image of the brain showed a mass lesion in the pituitary fossa. A trans-sphenoidal surgical procedure was performed which revealed a dark- yellowish hematoma. Microscopic examination showed diffuse infiltration of lymphocytes and plasma cells with fibrosis in the anterior pituitary. Post- operatively the patient's headaches and nausea resolved. This indicates that lymphocytic hypophysitis may be associated with SLE.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalClinical and Experimental Rheumatology
Volume18
Issue number1
Publication statusPublished - 2000 Feb 29

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Keywords

  • Lymphocytic hypophysitis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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