A case of lymphocytic hypophysitis in a patient with systemic lupus erythematosus is described. A 20-year-old woman was admitted to our hospital with generalized myalgia and facial rash in May 1998. The patient had a medical history, physical examination, and laboratory findings compatible with systemic lupus erythematosus (SLE). Headache and nausea had developed 3 months previously and worsened over the following months. Hormonal investigation showed hypopituitarism except for prolactin. A magnetic resonance image of the brain showed a mass lesion in the pituitary fossa. A trans-sphenoidal surgical procedure was performed which revealed a dark- yellowish hematoma. Microscopic examination showed diffuse infiltration of lymphocytes and plasma cells with fibrosis in the anterior pituitary. Post- operatively the patient's headaches and nausea resolved. This indicates that lymphocytic hypophysitis may be associated with SLE.
|Number of pages||3|
|Journal||Clinical and Experimental Rheumatology|
|Publication status||Published - 2000 Feb 29|
- Lymphocytic hypophysitis
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology and Allergy