Lymphocytic hypophysitis in a patient with systemic lupus erythematosus

J. D. Ji, S. Y. Lee, S. J. Choi, Y. H. Lee, Gwan Gyu Song

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


A case of lymphocytic hypophysitis in a patient with systemic lupus erythematosus is described. A 20-year-old woman was admitted to our hospital with generalized myalgia and facial rash in May 1998. The patient had a medical history, physical examination, and laboratory findings compatible with systemic lupus erythematosus (SLE). Headache and nausea had developed 3 months previously and worsened over the following months. Hormonal investigation showed hypopituitarism except for prolactin. A magnetic resonance image of the brain showed a mass lesion in the pituitary fossa. A trans-sphenoidal surgical procedure was performed which revealed a dark- yellowish hematoma. Microscopic examination showed diffuse infiltration of lymphocytes and plasma cells with fibrosis in the anterior pituitary. Post- operatively the patient's headaches and nausea resolved. This indicates that lymphocytic hypophysitis may be associated with SLE.

Original languageEnglish
Pages (from-to)78-80
Number of pages3
JournalClinical and experimental rheumatology
Issue number1
Publication statusPublished - 2000
Externally publishedYes


  • Lymphocytic hypophysitis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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