Lysine-specific demethylase 3A is important for autophagic occurrence

Joomyung Kim, Seon Ah Choi, Jaebeom Kim, Hyunkyung Kim, Sung Hee Baek

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here, we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy. Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for autophagy-related diseases.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalBiochemical and biophysical research communications
Volume526
Issue number1
DOIs
Publication statusPublished - 2020 May 21

Keywords

  • Autophagy
  • H3K9 demethylation
  • KDM3A

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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