M-13 bacteriophage based structural color sensor for detecting antibiotics

Jong Sik Moon, Minji Park, Won Geun Kim, Chuntae Kim, Jinyoung Hwang, Daun Seol, Chang Seok Kim, Jong Ryeul Sohn, Hoeil Chung, Jin Woo Oh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Color sensor systems that exploit the advantages of M-13 bacteriophage have been shown to be potentially useful for detection of hazardous materials. The properties of M-13 bacteriophage can be systemically modified to impart target-specific selectivity and sensitivity using the phage display technique. Here, we describe a structural color-based sensor that utilizes genetically engineered M-13 bacteriophage to discriminate different types of antibiotics. An M-13 bacteriophage based structural color matrix was fabricated using a simple pulling technique by self-assembly of M-13 bacteriophage. When exposed to organic solvent, M-13 bacteriophage bundles promptly swell and promote distinct structural color change. Color sensors composed of M-13 bacteriophage genetically engineered to possess WHW peptide motifs clearly discriminated three different types of antibiotics, which was based on the color analysis of sensor using principal component analysis. Our sensing approach based on M-13 bacteriophage could be a promising sensor technique such as an environmental monitoring system.

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume240
DOIs
Publication statusPublished - 2017 Mar 1

Keywords

  • Antibiotics
  • Biophotonics
  • Color sensor
  • M-13 bacteriophage
  • Self-assembly
  • Virus

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'M-13 bacteriophage based structural color sensor for detecting antibiotics'. Together they form a unique fingerprint.

  • Cite this

    Moon, J. S., Park, M., Kim, W. G., Kim, C., Hwang, J., Seol, D., Kim, C. S., Sohn, J. R., Chung, H., & Oh, J. W. (2017). M-13 bacteriophage based structural color sensor for detecting antibiotics. Sensors and Actuators, B: Chemical, 240, 757-762. https://doi.org/10.1016/j.snb.2016.09.050