Macrophages as cell-based delivery systems for nanoshells in photothermal therapy

Steen J. Madsen, Seung-Kuk Baek, Amani R. Makkouk, Tatiana Krasieva, Henry Hirschberg

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood-brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold-silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold-silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies.

Original languageEnglish
Pages (from-to)507-515
Number of pages9
JournalAnnals of Biomedical Engineering
Volume40
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Fingerprint

Nanoshells
Macrophages
Glioma
Blood-Brain Barrier
Silicon Dioxide
Gold
Nanoparticles
Silica
Therapeutics
Poisons
Phagocytosis
Brain
Animals
Hot Temperature
Infrared radiation
Growth
Neoplasms

Keywords

  • Blood-brain barrier
  • Gliomas
  • Gold-silica nanoshells
  • Macrophages
  • Nanoparticles
  • Spheroids

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Macrophages as cell-based delivery systems for nanoshells in photothermal therapy. / Madsen, Steen J.; Baek, Seung-Kuk; Makkouk, Amani R.; Krasieva, Tatiana; Hirschberg, Henry.

In: Annals of Biomedical Engineering, Vol. 40, No. 2, 01.02.2012, p. 507-515.

Research output: Contribution to journalArticle

Madsen, Steen J. ; Baek, Seung-Kuk ; Makkouk, Amani R. ; Krasieva, Tatiana ; Hirschberg, Henry. / Macrophages as cell-based delivery systems for nanoshells in photothermal therapy. In: Annals of Biomedical Engineering. 2012 ; Vol. 40, No. 2. pp. 507-515.
@article{10e25f2067184248831a6fe94e75b04c,
title = "Macrophages as cell-based delivery systems for nanoshells in photothermal therapy",
abstract = "Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood-brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold-silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold-silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies.",
keywords = "Blood-brain barrier, Gliomas, Gold-silica nanoshells, Macrophages, Nanoparticles, Spheroids",
author = "Madsen, {Steen J.} and Seung-Kuk Baek and Makkouk, {Amani R.} and Tatiana Krasieva and Henry Hirschberg",
year = "2012",
month = "2",
day = "1",
doi = "10.1007/s10439-011-0415-1",
language = "English",
volume = "40",
pages = "507--515",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Macrophages as cell-based delivery systems for nanoshells in photothermal therapy

AU - Madsen, Steen J.

AU - Baek, Seung-Kuk

AU - Makkouk, Amani R.

AU - Krasieva, Tatiana

AU - Hirschberg, Henry

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood-brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold-silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold-silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies.

AB - Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood-brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold-silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold-silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies.

KW - Blood-brain barrier

KW - Gliomas

KW - Gold-silica nanoshells

KW - Macrophages

KW - Nanoparticles

KW - Spheroids

UR - http://www.scopus.com/inward/record.url?scp=84858793809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858793809&partnerID=8YFLogxK

U2 - 10.1007/s10439-011-0415-1

DO - 10.1007/s10439-011-0415-1

M3 - Article

C2 - 21979168

AN - SCOPUS:84858793809

VL - 40

SP - 507

EP - 515

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 2

ER -