Magnesium corrosion triggered spontaneous generation of H2O2 on oxidized titanium for promoting angiogenesis

Jimin Park, Ping Du, Jin Kyung Jeon, Gun Hyuk Jang, Mintai Peter Hwang, Hyung Seop Han, Kwideok Park, Kwan Hyi Lee, Jee Wook Lee, Hojeong Jeon, Yu Chan Kim, Jong Woong Park, Hyun Kwang Seok, Myoung Ryul Ok

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au-decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated. Useful corrosion: An electrochemical system consisting of a biodegradable metal (Mg) and an oxygen-reduction-reaction catalyst was developed for spontaneous H2O2 generation. The controlled release of H2O2 promoted in vitro angiogenesis in the absence of any growth factors. A conventional titanium implant functionalized by simple magnesium incorporation thus also supports angiogenesis.

Original languageEnglish
Pages (from-to)14753-14757
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number49
DOIs
Publication statusPublished - 2015

Fingerprint

Titanium
Magnesium
Corrosion
Oxygen
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
Metals
Electrochemical corrosion
Catalysts
Electrons
Electric potential

Keywords

  • angiogenesis
  • catalysis
  • corrosion
  • magnesium
  • oxygen reduction reaction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Magnesium corrosion triggered spontaneous generation of H2O2 on oxidized titanium for promoting angiogenesis. / Park, Jimin; Du, Ping; Jeon, Jin Kyung; Jang, Gun Hyuk; Hwang, Mintai Peter; Han, Hyung Seop; Park, Kwideok; Lee, Kwan Hyi; Lee, Jee Wook; Jeon, Hojeong; Kim, Yu Chan; Park, Jong Woong; Seok, Hyun Kwang; Ok, Myoung Ryul.

In: Angewandte Chemie - International Edition, Vol. 54, No. 49, 2015, p. 14753-14757.

Research output: Contribution to journalArticle

Park, J, Du, P, Jeon, JK, Jang, GH, Hwang, MP, Han, HS, Park, K, Lee, KH, Lee, JW, Jeon, H, Kim, YC, Park, JW, Seok, HK & Ok, MR 2015, 'Magnesium corrosion triggered spontaneous generation of H2O2 on oxidized titanium for promoting angiogenesis', Angewandte Chemie - International Edition, vol. 54, no. 49, pp. 14753-14757. https://doi.org/10.1002/anie.201507352
Park, Jimin ; Du, Ping ; Jeon, Jin Kyung ; Jang, Gun Hyuk ; Hwang, Mintai Peter ; Han, Hyung Seop ; Park, Kwideok ; Lee, Kwan Hyi ; Lee, Jee Wook ; Jeon, Hojeong ; Kim, Yu Chan ; Park, Jong Woong ; Seok, Hyun Kwang ; Ok, Myoung Ryul. / Magnesium corrosion triggered spontaneous generation of H2O2 on oxidized titanium for promoting angiogenesis. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 49. pp. 14753-14757.
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