Magnetic barcoded hydrogel microparticles for multiplexed detection

Ki Wan Bong, Stephen C. Chapin, Patrick S. Doyle

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Magnetic polymer particles have been used in a wide variety of applications ranging from targeting and separation to diagnostics and imaging. Current synthesis methods have limited these particles to spherical or deformations of spherical morphologies. In this paper, we report the use of stop flow lithography to produce magnetic hydrogel microparticles with a graphical code region, a probe region, and a magnetic tail region. These anisotropic multifunctional magnetic polymer particles are an enhanced version of previously synthesized "barcoded" particles ( Science, 2007,315,1393-1396) developed for the sensitive and rapid multiplexed sensing of nucleic acids. The newly added magnetic region has acquired, dipole moments in the presence of weak homogeneous magnetic fields, allowing the particles to align along the applied field, direction. The novel magnetic properties have led to practical applications in the efficient orientation and separation of the barcoded microparticles during biological assays without disrupting detection capabilities.

Original languageEnglish
Pages (from-to)8008-8014
Number of pages7
JournalLangmuir
Volume26
Issue number11
DOIs
Publication statusPublished - 2010 Jun 1
Externally publishedYes

Fingerprint

Hydrogel
microparticles
Hydrogels
Polymers
Nucleic acids
Dipole moment
Diagnostic Imaging
Magnetic Fields
Biological Assay
Lithography
Nucleic Acids
Particles (particulate matter)
Assays
Magnetic properties
Magnetic fields
Imaging techniques
disrupting
polymers
nucleic acids
dipole moments

ASJC Scopus subject areas

  • Electrochemistry
  • Spectroscopy
  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces

Cite this

Magnetic barcoded hydrogel microparticles for multiplexed detection. / Bong, Ki Wan; Chapin, Stephen C.; Doyle, Patrick S.

In: Langmuir, Vol. 26, No. 11, 01.06.2010, p. 8008-8014.

Research output: Contribution to journalArticle

Bong, Ki Wan ; Chapin, Stephen C. ; Doyle, Patrick S. / Magnetic barcoded hydrogel microparticles for multiplexed detection. In: Langmuir. 2010 ; Vol. 26, No. 11. pp. 8008-8014.
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