Magnetic nanocomplexes and the physiological challenges associated with their use for cancer imaging and therapy

Eunjung Kim, Kwangyeol Lee, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Magnetic nanoparticles offer potential advances in cancer treatment. One example is cancer theranostics, which refers to the combination of a diagnostic tool, i.e., magnetic resonance (MR) imaging, and therapeutic entities such as drugs, oligonucleotides, antibodies, and peptides. They can be conjugated with bioactive molecules and have the ability to form a magnetic field gradient under an external magnetic field. They can offer a variety of active drug delivery and imaging strategies along with modalities such as magnetic hyperthermia. Imaging with magnetic nanoparticles can facilitate more effective cancer therapy through more well informed decision-making. In this article, we review notable progress in magnetic particle design, including surface modifications and multi-functionalization, and we discuss the recent bioapplications of magnetic nanoparticles in simultaneous cancer imaging and therapy.

Original languageEnglish
Pages (from-to)729-739
Number of pages11
JournalJournal of Materials Chemistry B
Volume1
Issue number6
DOIs
Publication statusPublished - 2013 Feb 14

Fingerprint

Nanoparticles
Imaging techniques
Magnetic Fields
Neoplasms
Magnetic fields
Aptitude
Oncology
Oligonucleotides
Magnetic resonance
Therapeutics
Drug delivery
Antibodies
Pharmaceutical Preparations
Peptides
Surface treatment
Decision Making
Fever
Decision making
Magnetic Resonance Imaging
Molecules

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

Cite this

Magnetic nanocomplexes and the physiological challenges associated with their use for cancer imaging and therapy. / Kim, Eunjung; Lee, Kwangyeol; Huh, Yong Min; Haam, Seungjoo.

In: Journal of Materials Chemistry B, Vol. 1, No. 6, 14.02.2013, p. 729-739.

Research output: Contribution to journalArticle

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