Magnetic nanocomplexes and the physiological challenges associated with their use for cancer imaging and therapy

Eunjung Kim, Kwangyeol Lee, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Magnetic nanoparticles offer potential advances in cancer treatment. One example is cancer theranostics, which refers to the combination of a diagnostic tool, i.e., magnetic resonance (MR) imaging, and therapeutic entities such as drugs, oligonucleotides, antibodies, and peptides. They can be conjugated with bioactive molecules and have the ability to form a magnetic field gradient under an external magnetic field. They can offer a variety of active drug delivery and imaging strategies along with modalities such as magnetic hyperthermia. Imaging with magnetic nanoparticles can facilitate more effective cancer therapy through more well informed decision-making. In this article, we review notable progress in magnetic particle design, including surface modifications and multi-functionalization, and we discuss the recent bioapplications of magnetic nanoparticles in simultaneous cancer imaging and therapy.

Original languageEnglish
Pages (from-to)729-739
Number of pages11
JournalJournal of Materials Chemistry B
Volume1
Issue number6
DOIs
Publication statusPublished - 2013 Feb 14

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ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

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