Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy

Ki Choon Sim, Deuk Jae Sung, Kun Woo Kang, Kyung Sook Yang, Na Yeon Han, Beomjin Park, Min Ju Kim, Sung Bum Cho

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume41
Issue number5
DOIs
Publication statusPublished - 2017 Sep 1

Keywords

  • Gleason score
  • magnetic resonance imaging
  • prostate cancer
  • prostate-specific antigen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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