Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy

Ki Choon Sim, Deuk Jae Sung, Kun Woo Kang, Kyung Sook Yang, Na Yeon Han, Beomjin Park, Min Ju Kim, Sung Bum Cho

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume41
Issue number5
DOIs
Publication statusPublished - 2017 Sep 1

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Neoplasm Grading
Prostate-Specific Antigen
Prostatic Neoplasms
Magnetic Resonance Imaging
Biopsy
Prostate
Prostatectomy
ROC Curve
Area Under Curve
Logistic Models

Keywords

  • Gleason score
  • magnetic resonance imaging
  • prostate cancer
  • prostate-specific antigen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy",
abstract = "Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.",
keywords = "Gleason score, magnetic resonance imaging, prostate cancer, prostate-specific antigen",
author = "Sim, {Ki Choon} and Sung, {Deuk Jae} and Kang, {Kun Woo} and Yang, {Kyung Sook} and Han, {Na Yeon} and Beomjin Park and Kim, {Min Ju} and Cho, {Sung Bum}",
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T1 - Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy

AU - Sim, Ki Choon

AU - Sung, Deuk Jae

AU - Kang, Kun Woo

AU - Yang, Kyung Sook

AU - Han, Na Yeon

AU - Park, Beomjin

AU - Kim, Min Ju

AU - Cho, Sung Bum

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Y1 - 2017/9/1

N2 - Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.

AB - Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.

KW - Gleason score

KW - magnetic resonance imaging

KW - prostate cancer

KW - prostate-specific antigen

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