Abstract
Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 731-736 |
| Number of pages | 6 |
| Journal | Journal of Computer Assisted Tomography |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2017 Sep 1 |
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Keywords
- Gleason score
- magnetic resonance imaging
- prostate cancer
- prostate-specific antigen
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy. / Sim, Ki Choon; Sung, Deuk Jae; Kang, Kun Woo; Yang, Kyung Sook; Han, Na Yeon; Park, Beomjin; Kim, Min Ju; Cho, Sung Bum.
In: Journal of Computer Assisted Tomography, Vol. 41, No. 5, 01.09.2017, p. 731-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic Resonance Imaging-Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients with Low-Risk Prostate Cancer on Initial Biopsy
AU - Sim, Ki Choon
AU - Sung, Deuk Jae
AU - Kang, Kun Woo
AU - Yang, Kyung Sook
AU - Han, Na Yeon
AU - Park, Beomjin
AU - Kim, Min Ju
AU - Cho, Sung Bum
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.
AB - Objective The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging-based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions Magnetic resonance imaging-based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.
KW - Gleason score
KW - magnetic resonance imaging
KW - prostate cancer
KW - prostate-specific antigen
UR - http://www.scopus.com/inward/record.url?scp=85030612050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030612050&partnerID=8YFLogxK
U2 - 10.1097/RCT.0000000000000579
DO - 10.1097/RCT.0000000000000579
M3 - Article
C2 - 28914751
AN - SCOPUS:85030612050
VL - 41
SP - 731
EP - 736
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 5
ER -