Magnetic resonance imaging using chemical exchange saturation transfer

Jaeseok Park

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic resonance imaging (MRI) has been widely used as a valuable diagnostic imaging modality that exploits water content and water relaxation properties to provide both structural and functional information with high resolution. Chemical exchange saturation transfer (CEST) in MRI has been recently introduced as a new mechanism of image contrast, wherein exchangeable protons from mobile proteins and peptides are indirectly detected through saturation transfer and are not observable using conventional MRI. It has been demonstrated that CEST MRI can detect important tissue metabolites and byproducts such as glucose, glycogen, and lactate. Additionally, CEST MRI is sensitive to pH or temperature and can calibrate microenvironment dependent on pH or temperature. In this work, we provide an overview on recent trends in CEST MRI, introducing general principles of CEST mechanism, quantitative description of proton transfer process between water pool and exchangeable solute pool in the presence or absence of conventional magnetization transfer effect, and its applications

Original languageEnglish
Title of host publicationNanosystems in Engineering and Medicine
DOIs
Publication statusPublished - 2012
EventNanosystems in Engineering and Medicine - Incheon, Korea, Republic of
Duration: 2012 Sep 102012 Sep 12

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8548
ISSN (Print)1605-7422

Other

OtherNanosystems in Engineering and Medicine
CountryKorea, Republic of
CityIncheon
Period12/9/1012/9/12

Keywords

  • Chemical exchange saturation transfer
  • Magnetic resonance imaging
  • Molecular imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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