Magnetically driven spinning nanowires as effective materials for eradicating living cells

Daniel S. Choi; Xiaoping Hopkins; Rosemarie Kringel; Jungrae Park; In Tak Jeon; Young Keun Kim

doi:10.1063/1.3678437

Magnetically driven spinning nanowires as effective materials for eradicating living cells

Daniel S. Choi, Xiaoping Hopkins, Rosemarie Kringel, Jungrae Park, In Tak Jeon, Young Keun Kim

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We present a method to inflame cells, in vitro, by applying an alternating current (ac) magnetic field to ferromagnetic nanowires (NWs) internalized by living cells. Nickel (Ni) NWs were internalized by human embryonic kidney cells (HEK-293). The application of ac magnetic field to the cells induced spinning of the cells via the motion of internalized NWs. This resulted in cell death by physically causing damage. A study of the response of cytokine to cells with spinning NWs shows increased interleukin-6 effects when compared with responses from non-spinning cells. The spinning effect of cells caused by the application of magnetic field can be used to target and inflame the cells. Such experiments suggest the possibility of inflaming cells for the treatment of cancer.

Original language	English
Article number	07B329
Journal	Journal of Applied Physics
Volume	111
Issue number	7
DOIs	https://doi.org/10.1063/1.3678437
Publication status	Published - 2012 Apr 1

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.3678437

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title = "Magnetically driven spinning nanowires as effective materials for eradicating living cells",

abstract = "We present a method to inflame cells, in vitro, by applying an alternating current (ac) magnetic field to ferromagnetic nanowires (NWs) internalized by living cells. Nickel (Ni) NWs were internalized by human embryonic kidney cells (HEK-293). The application of ac magnetic field to the cells induced spinning of the cells via the motion of internalized NWs. This resulted in cell death by physically causing damage. A study of the response of cytokine to cells with spinning NWs shows increased interleukin-6 effects when compared with responses from non-spinning cells. The spinning effect of cells caused by the application of magnetic field can be used to target and inflame the cells. Such experiments suggest the possibility of inflaming cells for the treatment of cancer.",

author = "Choi, {Daniel S.} and Xiaoping Hopkins and Rosemarie Kringel and Jungrae Park and Jeon, {In Tak} and {Keun Kim}, Young",

note = "Funding Information: The authors acknowledge the financial support of the University of Idaho Biological Applications of Nanotechnology (BANTech) Funds. This research was also supported by the Leap Research Program (No. 2011-0016497) and the Pioneer Research Center Program (No. 2011-0002128) through the National Research Foundation of Korea.",

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doi = "10.1063/1.3678437",

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T1 - Magnetically driven spinning nanowires as effective materials for eradicating living cells

AU - Choi, Daniel S.

AU - Hopkins, Xiaoping

AU - Kringel, Rosemarie

AU - Park, Jungrae

AU - Jeon, In Tak

AU - Keun Kim, Young

N1 - Funding Information: The authors acknowledge the financial support of the University of Idaho Biological Applications of Nanotechnology (BANTech) Funds. This research was also supported by the Leap Research Program (No. 2011-0016497) and the Pioneer Research Center Program (No. 2011-0002128) through the National Research Foundation of Korea.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - We present a method to inflame cells, in vitro, by applying an alternating current (ac) magnetic field to ferromagnetic nanowires (NWs) internalized by living cells. Nickel (Ni) NWs were internalized by human embryonic kidney cells (HEK-293). The application of ac magnetic field to the cells induced spinning of the cells via the motion of internalized NWs. This resulted in cell death by physically causing damage. A study of the response of cytokine to cells with spinning NWs shows increased interleukin-6 effects when compared with responses from non-spinning cells. The spinning effect of cells caused by the application of magnetic field can be used to target and inflame the cells. Such experiments suggest the possibility of inflaming cells for the treatment of cancer.

AB - We present a method to inflame cells, in vitro, by applying an alternating current (ac) magnetic field to ferromagnetic nanowires (NWs) internalized by living cells. Nickel (Ni) NWs were internalized by human embryonic kidney cells (HEK-293). The application of ac magnetic field to the cells induced spinning of the cells via the motion of internalized NWs. This resulted in cell death by physically causing damage. A study of the response of cytokine to cells with spinning NWs shows increased interleukin-6 effects when compared with responses from non-spinning cells. The spinning effect of cells caused by the application of magnetic field can be used to target and inflame the cells. Such experiments suggest the possibility of inflaming cells for the treatment of cancer.

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DO - 10.1063/1.3678437

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JF - Journal of Applied Physics

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ER -

Magnetically driven spinning nanowires as effective materials for eradicating living cells

Abstract

ASJC Scopus subject areas

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