Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing

Alexander H. Mo, Preston B. Landon, Karla Santacruz Gomez, Heemin Kang, Joon Lee, Chen Zhang, Woraphong Janetanakit, Vrinda Sant, Tianyu Lu, David A. Colburn, Siddhartha Akkiraju, Samuel Dossou, Yue Cao, Kuo Fen Lee, Shyni Varghese, Gennadi Glinsky, Ratnesh Lal

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Original languageEnglish
Pages (from-to)11840-11850
Number of pages11
JournalNanoscale
Volume8
Issue number23
DOIs
Publication statusPublished - 2016 Jun 21
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)

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    Mo, A. H., Landon, P. B., Gomez, K. S., Kang, H., Lee, J., Zhang, C., Janetanakit, W., Sant, V., Lu, T., Colburn, D. A., Akkiraju, S., Dossou, S., Cao, Y., Lee, K. F., Varghese, S., Glinsky, G., & Lal, R. (2016). Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. Nanoscale, 8(23), 11840-11850. https://doi.org/10.1039/c6nr02445a