Malignant glomus tumors of the stomach- a report of 2 cases with multiple metastases-

Hyunjoo Lee, Yoon Seok Choi, Sang Cheul Oh, Jong Jae Park, Chul Hwan Kim, Han Kyeom Kim, Insun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glomus tumors are mesenchymal neoplasms usually developing in the dermis or subcutis of the extremities. The majority of glomus tumors are entirely benign, and malignant glomus tumors are very rare, especially those arising in the visceral organs. Here, we are presenting two cases of malignant glomus tumor, initially diagnosed in the stomach by endoscopic biopsy. Case 1 was found in the stomach, right kidney, brain and humerus of a 65-year-old woman, and Case 2 in the stomach and liver of a 63-year-old man. Histologically, the tumor was composed of solid sheets and nests of round and short-spindle shaped tumor cells with vesicular nucleus and prominent nucleolus. The tumor cells were closely admixed with blood vessels of varying size. Immunohistochemically, the tumor cells showed diffuse and strong positive staining for smooth muscle actin and paranuclear, dot-like staining for synaptophysin, but negative for desmin, c-kit, CD34 and S-100 protein. These two are rare cases of a malignant glomus tumor with widespread metastases.

Original languageEnglish
Pages (from-to)358-363
Number of pages6
JournalKorean Journal of Pathology
Volume43
Issue number4
DOIs
Publication statusPublished - 2009 Aug 1

Fingerprint

Glomus Tumor
Stomach
Neoplasm Metastasis
Neoplasms
Negative Staining
Synaptophysin
Desmin
S100 Proteins
Humerus
Dermis
Smooth Muscle
Blood Vessels
Actins
Extremities
Staining and Labeling
Kidney
Biopsy
Liver
Brain

Keywords

  • Brain
  • Glomus tumor
  • Kidney
  • Neoplasm metastasis
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Malignant glomus tumors of the stomach- a report of 2 cases with multiple metastases-. / Lee, Hyunjoo; Choi, Yoon Seok; Oh, Sang Cheul; Park, Jong Jae; Kim, Chul Hwan; Kim, Han Kyeom; Kim, Insun.

In: Korean Journal of Pathology, Vol. 43, No. 4, 01.08.2009, p. 358-363.

Research output: Contribution to journalArticle

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AB - Glomus tumors are mesenchymal neoplasms usually developing in the dermis or subcutis of the extremities. The majority of glomus tumors are entirely benign, and malignant glomus tumors are very rare, especially those arising in the visceral organs. Here, we are presenting two cases of malignant glomus tumor, initially diagnosed in the stomach by endoscopic biopsy. Case 1 was found in the stomach, right kidney, brain and humerus of a 65-year-old woman, and Case 2 in the stomach and liver of a 63-year-old man. Histologically, the tumor was composed of solid sheets and nests of round and short-spindle shaped tumor cells with vesicular nucleus and prominent nucleolus. The tumor cells were closely admixed with blood vessels of varying size. Immunohistochemically, the tumor cells showed diffuse and strong positive staining for smooth muscle actin and paranuclear, dot-like staining for synaptophysin, but negative for desmin, c-kit, CD34 and S-100 protein. These two are rare cases of a malignant glomus tumor with widespread metastases.

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