Malignant inverted papilloma of the urinary bladder: the histopathological aspect of malignant potential of inverted papilloma.

J. Cheon, H. K. Kim, J. J. Kim, D. K. Yoon, S. K. Koh, I. S. Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To investigate the histopathological characteristics of inverted papillomas of the urinary bladder, including the possibility of malignant transformation, we studied the indicators of cellular proliferation activity in 7 inverted papillomas of the bladder including two cases of malignant inverted papilloma of the bladder. PCNA expression rates in two cases of malignant inverted papilloma were higher than in benign inverted papillomas. Mean numbers of AgNORs per nucleus in malignant inverted papillomas were much more than in benign inverted papillomas. The c-erbB-2 oncoprotein was expressed only in malignant inverted papillomas. These results suggest that PCNA expression rate, mean number of AgNORs per nucleus and c-erB-2 oncoprotein expression may be merited as good indicators to detect the inverted papilloma with more proliferative and aggressive lesions, and with the potential of malignant transformation.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalJournal of Korean medical science
Volume10
Issue number2
DOIs
Publication statusPublished - 1995 Apr

ASJC Scopus subject areas

  • Medicine(all)

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