Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice

Stanley Kosanke, Susan M. Edgerton, Dan Moore, XiaoHe Yang, Terza Mason, Kathy Alvarez, Lynn Jones, Aeree Kim, Ann D. Thor

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phenotypic and biological heterogeneity was studied in a single transgenic mouse model to determine the level of biological variance. We analyzed 1,258 tumors from 417 MMTV-wt-ErbB-2 transgenic mice, subdivided by casein or soy-based dietary randomization and hormonal treatment. Variance in tumor histologic features, growth pattern, invasion, metastases, and multi-focality were detected in untreated and treated mice. Ninety-three percent (1,174/1,258) of tumors had the solid growth pattern widely reported in this model. However, among the solid tumors, a spectrum of growth patterns, from well-circumscribed tumors with a pseudocapsule to locally invasive or highly aggressive, metastatic subtype, was observed. Of the non-solid tumors, glandular features were prominent in 84 (7%). Adenocarcinomas included papillary, acinar/glandular, and adenosquamous subtypes. Adenosquamous tumors were exclusively observed in the group of mice treated on a short-term basis with estrogen. In contrast to the reported literature for this transgenic mouse model, mammary tumors were multifocal in the majority of cases (303 of 417 mice, or 73%). Results of this extensive study of a single transgenic model of mammary tumorigenesis indicate phenotypic and biological heterogeneity not previously associated with this transgenic mouse. These data support a complex, multistep process of carcinogenesis and clonal evolution, with biological and phenotypic variance similar to that observed in human mammary cancer development.

Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalComparative Medicine
Volume54
Issue number3
Publication statusPublished - 2004 Jun 1

Fingerprint

mammary neoplasms (animal)
Transgenic Mice
Tumors
genetically modified organisms
Breast Neoplasms
neoplasms
mice
Neoplasms
Carcinogenesis
carcinogenesis
breasts
Growth
Clonal Evolution
Papillary Adenocarcinoma
animal models
Random Allocation
Caseins
adenocarcinoma
phenotypic variation
metastasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kosanke, S., Edgerton, S. M., Moore, D., Yang, X., Mason, T., Alvarez, K., ... Thor, A. D. (2004). Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. Comparative Medicine, 54(3), 280-287.

Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. / Kosanke, Stanley; Edgerton, Susan M.; Moore, Dan; Yang, XiaoHe; Mason, Terza; Alvarez, Kathy; Jones, Lynn; Kim, Aeree; Thor, Ann D.

In: Comparative Medicine, Vol. 54, No. 3, 01.06.2004, p. 280-287.

Research output: Contribution to journalArticle

Kosanke, S, Edgerton, SM, Moore, D, Yang, X, Mason, T, Alvarez, K, Jones, L, Kim, A & Thor, AD 2004, 'Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice', Comparative Medicine, vol. 54, no. 3, pp. 280-287.
Kosanke S, Edgerton SM, Moore D, Yang X, Mason T, Alvarez K et al. Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. Comparative Medicine. 2004 Jun 1;54(3):280-287.
Kosanke, Stanley ; Edgerton, Susan M. ; Moore, Dan ; Yang, XiaoHe ; Mason, Terza ; Alvarez, Kathy ; Jones, Lynn ; Kim, Aeree ; Thor, Ann D. / Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. In: Comparative Medicine. 2004 ; Vol. 54, No. 3. pp. 280-287.
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