Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients

Seung Gul Kang, Jung Eun Choi, Hyonggin An, Young Min Park, Heon-Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Sook Haeng Joe, In Kwa Jung, Leen Kim, Min-Soo Lee

Research output: Contribution to journalArticle

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Abstract

Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.

Original languageEnglish
Pages (from-to)1844-1847
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number8
DOIs
Publication statusPublished - 2008 Dec 12

Fingerprint

Dyskinesias
Superoxide Dismutase
Genes
Single Nucleotide Polymorphism
Antipsychotic Agents
Tardive Dyskinesia
Logistic Models
Alleles
Regression Analysis
Population

Keywords

  • Abnormal involuntary movements
  • Manganese superoxide dismutase
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. / Kang, Seung Gul; Choi, Jung Eun; An, Hyonggin; Park, Young Min; Lee, Heon-Jeong; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Cho, Sung Nam; Joe, Sook Haeng; Jung, In Kwa; Kim, Leen; Lee, Min-Soo.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 8, 12.12.2008, p. 1844-1847.

Research output: Contribution to journalArticle

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abstract = "Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.",
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AU - Lee, Heon-Jeong

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AU - Kim, Yong Ku

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AU - Lee, Min-Soo

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