Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light

Yaguang Ren, Adam C. Sedgwick, Jingqin Chen, Gregory Thiabaud, Calvin V. Chau, Jusung An, Jonathan F. Arambula, Xiao Peng He, Jong Seung Kim, Jonathan L. Sessler, Chengbo Liu

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, MMn provided the greatest PA signal intensities in both doubly distilled water and RAW 264.7 cells. In vivo experiments using a prostate tumor mouse model were performed. MMn displayed no adverse toxicity to major organs as inferred from hematoxylin and eosin (H&E) staining and cell blood count testing. MMn also allowed for PA-based imaging of tumors with excellent in vivo stability to provide 3D tumor diagnostic information. Based on the present findings and previous magnetic resonance imaging (MRI) studies, we believe MMn may have a role to play either as a stand-alone PA contrast agent or as a single molecule dual modal (PA and MR) imaging agent for tumor diagnosis.

Original languageEnglish
Pages (from-to)16156-16160
Number of pages5
JournalJournal of the American Chemical Society
Issue number38
Publication statusPublished - 2020 Sept 23

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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