TY - JOUR
T1 - Manganese(II) Texaphyrin
T2 - A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light
AU - Ren, Yaguang
AU - Sedgwick, Adam C.
AU - Chen, Jingqin
AU - Thiabaud, Gregory
AU - Chau, Calvin V.
AU - An, Jusung
AU - Arambula, Jonathan F.
AU - He, Xiao Peng
AU - Kim, Jong Seung
AU - Sessler, Jonathan L.
AU - Liu, Chengbo
N1 - Funding Information:
C.L. thanks the National Natural Science Foundation of China for funding (NSFC) (Nos. 91739117, 81927807, 61705139) and CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology (2011DP173015); Shenzhen Key Laboratory for Molecular Imaging (ZDSY20130401165820357); Guangdong Provincial Key Laboratory of Biomedical Optical Imaging (2020B121201010). X.P.H. thanks the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), and the international cooperation program of Shanghai Science and Technology Committee (17520750100). J.S.K. thanks the CRI project (No. 2018r1a3b1052702) of the National Research Foundation of Korea for financial support. The work in Austin was supported by the National Institutes of Health (R01 CA 68682 to J.L.S.) and the Robert A. Welch Foundation (F-0018 to J.L.S. and R15 CA232765 to J.F.A.).
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/9/23
Y1 - 2020/9/23
N2 - The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, MMn provided the greatest PA signal intensities in both doubly distilled water and RAW 264.7 cells. In vivo experiments using a prostate tumor mouse model were performed. MMn displayed no adverse toxicity to major organs as inferred from hematoxylin and eosin (H&E) staining and cell blood count testing. MMn also allowed for PA-based imaging of tumors with excellent in vivo stability to provide 3D tumor diagnostic information. Based on the present findings and previous magnetic resonance imaging (MRI) studies, we believe MMn may have a role to play either as a stand-alone PA contrast agent or as a single molecule dual modal (PA and MR) imaging agent for tumor diagnosis.
AB - The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for photoacoustic (PA)-based imaging is explored in this study. All three complexes demonstrated excellent photostabilities; however, MMn provided the greatest PA signal intensities in both doubly distilled water and RAW 264.7 cells. In vivo experiments using a prostate tumor mouse model were performed. MMn displayed no adverse toxicity to major organs as inferred from hematoxylin and eosin (H&E) staining and cell blood count testing. MMn also allowed for PA-based imaging of tumors with excellent in vivo stability to provide 3D tumor diagnostic information. Based on the present findings and previous magnetic resonance imaging (MRI) studies, we believe MMn may have a role to play either as a stand-alone PA contrast agent or as a single molecule dual modal (PA and MR) imaging agent for tumor diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85091583636&partnerID=8YFLogxK
U2 - 10.1021/jacs.0c04387
DO - 10.1021/jacs.0c04387
M3 - Article
C2 - 32914968
AN - SCOPUS:85091583636
SN - 0002-7863
VL - 142
SP - 16156
EP - 16160
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -