Mankind's first natural stem cell transplant

Jose N. Tolosa, Dong-Hyuk Park, David J. Eve, Stephen K. Klasko, Cesario V. Borlongan, Paul R. Sanberg

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The timing of the umbilical cord clamping at birth is still controversial. In the modern era of medicine, the cord has been clamped early to facilitate resuscitation and stabilization of infants. However, recently delayed cord clamping has been supported by physicians because it allows for the physiological transfer of blood from the placenta to the infant. Many clinical studies have revealed that the delayed cord clamping elevates blood volume and haemoglobin and prevents anaemia in infants. Moreover, since it was known that umbilical cord blood contains various valuable stem cells such as haematopoietic stem cells, endothelial cell precursors, mesenchymal progenitors and multipotent/pluripotent lineage stem cells, the merit of delayed cord clamping has been magnified. In this review, we discuss the advantages and disadvantages of delayed cord clamping at birth. We highlight the importance of delayed cord clamping in realizing mankind's first stem cell transfer and propose that it should be encouraged in normal births.

Original languageEnglish
Pages (from-to)488-495
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume14
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Constriction
Stem Cells
Transplants
Parturition
Pluripotent Stem Cells
Modern 1601-history
Umbilical Cord
Hematopoietic Stem Cells
Blood Volume
Fetal Blood
Resuscitation
Placenta
Anemia
Hemoglobins
Endothelial Cells
Physicians

Keywords

  • Anaemia
  • Birth
  • Delayed cord clamping
  • Preterm
  • Stem cells
  • Umbilical cord blood

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

Tolosa, J. N., Park, D-H., Eve, D. J., Klasko, S. K., Borlongan, C. V., & Sanberg, P. R. (2010). Mankind's first natural stem cell transplant. Journal of Cellular and Molecular Medicine, 14(3), 488-495. https://doi.org/10.1111/j.1582-4934.2010.01029.x

Mankind's first natural stem cell transplant. / Tolosa, Jose N.; Park, Dong-Hyuk; Eve, David J.; Klasko, Stephen K.; Borlongan, Cesario V.; Sanberg, Paul R.

In: Journal of Cellular and Molecular Medicine, Vol. 14, No. 3, 01.03.2010, p. 488-495.

Research output: Contribution to journalArticle

Tolosa, JN, Park, D-H, Eve, DJ, Klasko, SK, Borlongan, CV & Sanberg, PR 2010, 'Mankind's first natural stem cell transplant', Journal of Cellular and Molecular Medicine, vol. 14, no. 3, pp. 488-495. https://doi.org/10.1111/j.1582-4934.2010.01029.x
Tolosa, Jose N. ; Park, Dong-Hyuk ; Eve, David J. ; Klasko, Stephen K. ; Borlongan, Cesario V. ; Sanberg, Paul R. / Mankind's first natural stem cell transplant. In: Journal of Cellular and Molecular Medicine. 2010 ; Vol. 14, No. 3. pp. 488-495.
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