TY - JOUR
T1 - Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development
AU - Xia, Jing
AU - Wang, Fan
AU - Wu, Zhengwang
AU - Wang, Li
AU - Zhang, Caiming
AU - Shen, Dinggang
AU - Li, Gang
N1 - Funding Information:
G. Li was supported in part by NIH grants (MH107815, MH116225, and MH117943). L. Wang was supported in part by NIH grants (MH109773 and MH117943). D. Shen was supported in part by NIH grant (MH117943). Thank Dr. Martin A. Styner and his colleagues for making the UNC-Wisconsin neurodevelopment rhesus MRI database publicly available.
Publisher Copyright:
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Studying cortical hemispheric asymmetries during the dynamic early postnatal stages in macaque monkeys (with close phylogenetic relationship to humans) would increase our limited understanding on the possible origins, developmental trajectories, and evolutional mechanisms of brain asymmetries in nonhuman primates, but remains a blind spot to the community. Via cortical surface-based morphometry, we comprehensively analyze hemispheric structural asymmetries in 134 longitudinal MRI scans from birth to 20 months of age from 32 healthy macaque monkeys. We reveal that most clusters of hemispheric asymmetries of cortical properties, such as surface area, cortical thickness, sulcal depth, and vertex positions, expand in the first 4 months of life, and evolve only moderately thereafter. Prominent hemispheric asymmetries are found at the inferior frontal gyrus, precentral gyrus, posterior temporal cortex, superior temporal gyrus (STG), superior temporal sulcus (STS), and cingulate cortex. Specifically, the left planum temporale and left STG consistently have larger area and thicker cortices than those on the right hemisphere, while the right STS, right cingulate cortex, and right anterior insula are consistently deeper than the left ones, partially consistent with the findings in human infants and adults. Our results thus provide a valuable reference in studying early brain development and evolution.
AB - Studying cortical hemispheric asymmetries during the dynamic early postnatal stages in macaque monkeys (with close phylogenetic relationship to humans) would increase our limited understanding on the possible origins, developmental trajectories, and evolutional mechanisms of brain asymmetries in nonhuman primates, but remains a blind spot to the community. Via cortical surface-based morphometry, we comprehensively analyze hemispheric structural asymmetries in 134 longitudinal MRI scans from birth to 20 months of age from 32 healthy macaque monkeys. We reveal that most clusters of hemispheric asymmetries of cortical properties, such as surface area, cortical thickness, sulcal depth, and vertex positions, expand in the first 4 months of life, and evolve only moderately thereafter. Prominent hemispheric asymmetries are found at the inferior frontal gyrus, precentral gyrus, posterior temporal cortex, superior temporal gyrus (STG), superior temporal sulcus (STS), and cingulate cortex. Specifically, the left planum temporale and left STG consistently have larger area and thicker cortices than those on the right hemisphere, while the right STS, right cingulate cortex, and right anterior insula are consistently deeper than the left ones, partially consistent with the findings in human infants and adults. Our results thus provide a valuable reference in studying early brain development and evolution.
KW - cortical development
KW - cortical thickness
KW - hemispheric asymmetries
KW - macaque monkeys
UR - http://www.scopus.com/inward/record.url?scp=85073942011&partnerID=8YFLogxK
U2 - 10.1002/hbm.24789
DO - 10.1002/hbm.24789
M3 - Article
C2 - 31532054
AN - SCOPUS:85073942011
VL - 41
SP - 95
EP - 106
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 1
ER -