Abstract
The human cerebral cortex develops rapidly and dynamically in the first 2 years of life. It has been shown that cortical surface expansion from term infant to adult is highly nonuniform in a cross-sectional study. However, little is known about the longitudinal cortical surface expansion during early postnatal stages. In this article, we generate the first longitudinal surface-based atlases of human cortical structures at 0, 1, and 2 years of age from 73 healthy subjects. On the basis of the surface-based atlases, we study the longitudinal cortical surface expansion in the first 2 years of life and find that cortical surface expansion is age related and region specific. In the first year, cortical surface expands dramatically, with an average expansion of 1.80 times. In particular, regions of superior and medial temporal, superior parietal, medial orbitofrontal, lateral anterior prefrontal, occipital cortices, and postcentral gyrus expand relatively larger than other regions. In the second year, cortical surface still expands substantially, with an average expansion of 1.20 times. In particular, regions of superior and middle frontal, orbitofrontal, inferior temporal, inferior parietal, and superior parietal cortices expand relatively larger than other regions. These region-specific patterns of cortical surface expansion are related to cognitive and functional development at these stages.
| Original language | English |
|---|---|
| Pages (from-to) | 2724-2733 |
| Number of pages | 10 |
| Journal | Cerebral Cortex |
| Volume | 23 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2013 Nov 1 |
| Externally published | Yes |
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Keywords
- cortical surface expansion
- infant cortical folding
- longitudinal cortical development
- longitudinal surface-based atlas
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
Cite this
Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age. / Li, Gang; Nie, Jingxin; Wang, Li; Shi, Feng; Lin, Weili; Gilmore, John H.; Shen, Dinggang.
In: Cerebral Cortex, Vol. 23, No. 11, 01.11.2013, p. 2724-2733.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age
AU - Li, Gang
AU - Nie, Jingxin
AU - Wang, Li
AU - Shi, Feng
AU - Lin, Weili
AU - Gilmore, John H.
AU - Shen, Dinggang
PY - 2013/11/1
Y1 - 2013/11/1
N2 - The human cerebral cortex develops rapidly and dynamically in the first 2 years of life. It has been shown that cortical surface expansion from term infant to adult is highly nonuniform in a cross-sectional study. However, little is known about the longitudinal cortical surface expansion during early postnatal stages. In this article, we generate the first longitudinal surface-based atlases of human cortical structures at 0, 1, and 2 years of age from 73 healthy subjects. On the basis of the surface-based atlases, we study the longitudinal cortical surface expansion in the first 2 years of life and find that cortical surface expansion is age related and region specific. In the first year, cortical surface expands dramatically, with an average expansion of 1.80 times. In particular, regions of superior and medial temporal, superior parietal, medial orbitofrontal, lateral anterior prefrontal, occipital cortices, and postcentral gyrus expand relatively larger than other regions. In the second year, cortical surface still expands substantially, with an average expansion of 1.20 times. In particular, regions of superior and middle frontal, orbitofrontal, inferior temporal, inferior parietal, and superior parietal cortices expand relatively larger than other regions. These region-specific patterns of cortical surface expansion are related to cognitive and functional development at these stages.
AB - The human cerebral cortex develops rapidly and dynamically in the first 2 years of life. It has been shown that cortical surface expansion from term infant to adult is highly nonuniform in a cross-sectional study. However, little is known about the longitudinal cortical surface expansion during early postnatal stages. In this article, we generate the first longitudinal surface-based atlases of human cortical structures at 0, 1, and 2 years of age from 73 healthy subjects. On the basis of the surface-based atlases, we study the longitudinal cortical surface expansion in the first 2 years of life and find that cortical surface expansion is age related and region specific. In the first year, cortical surface expands dramatically, with an average expansion of 1.80 times. In particular, regions of superior and medial temporal, superior parietal, medial orbitofrontal, lateral anterior prefrontal, occipital cortices, and postcentral gyrus expand relatively larger than other regions. In the second year, cortical surface still expands substantially, with an average expansion of 1.20 times. In particular, regions of superior and middle frontal, orbitofrontal, inferior temporal, inferior parietal, and superior parietal cortices expand relatively larger than other regions. These region-specific patterns of cortical surface expansion are related to cognitive and functional development at these stages.
KW - cortical surface expansion
KW - infant cortical folding
KW - longitudinal cortical development
KW - longitudinal surface-based atlas
UR - http://www.scopus.com/inward/record.url?scp=84885913969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885913969&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhs265
DO - 10.1093/cercor/bhs265
M3 - Article
C2 - 22923087
AN - SCOPUS:84885913969
VL - 23
SP - 2724
EP - 2733
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 11
ER -