Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age

Gang Li, Jingxin Nie, Li Wang, Feng Shi, Weili Lin, John H. Gilmore, Dinggang Shen

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The human cerebral cortex develops rapidly and dynamically in the first 2 years of life. It has been shown that cortical surface expansion from term infant to adult is highly nonuniform in a cross-sectional study. However, little is known about the longitudinal cortical surface expansion during early postnatal stages. In this article, we generate the first longitudinal surface-based atlases of human cortical structures at 0, 1, and 2 years of age from 73 healthy subjects. On the basis of the surface-based atlases, we study the longitudinal cortical surface expansion in the first 2 years of life and find that cortical surface expansion is age related and region specific. In the first year, cortical surface expands dramatically, with an average expansion of 1.80 times. In particular, regions of superior and medial temporal, superior parietal, medial orbitofrontal, lateral anterior prefrontal, occipital cortices, and postcentral gyrus expand relatively larger than other regions. In the second year, cortical surface still expands substantially, with an average expansion of 1.20 times. In particular, regions of superior and middle frontal, orbitofrontal, inferior temporal, inferior parietal, and superior parietal cortices expand relatively larger than other regions. These region-specific patterns of cortical surface expansion are related to cognitive and functional development at these stages.

Original languageEnglish
Pages (from-to)2724-2733
Number of pages10
JournalCerebral Cortex
Volume23
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1
Externally publishedYes

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Occipital Lobe
Atlases
Parturition
Parietal Lobe
Somatosensory Cortex
Prefrontal Cortex
Cerebral Cortex
Longitudinal Studies
Healthy Volunteers
Cross-Sectional Studies

Keywords

  • cortical surface expansion
  • infant cortical folding
  • longitudinal cortical development
  • longitudinal surface-based atlas

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age. / Li, Gang; Nie, Jingxin; Wang, Li; Shi, Feng; Lin, Weili; Gilmore, John H.; Shen, Dinggang.

In: Cerebral Cortex, Vol. 23, No. 11, 01.11.2013, p. 2724-2733.

Research output: Contribution to journalArticle

Li, Gang ; Nie, Jingxin ; Wang, Li ; Shi, Feng ; Lin, Weili ; Gilmore, John H. ; Shen, Dinggang. / Mapping region-specific longitudinal cortical surface expansion from birth to 2 years of age. In: Cerebral Cortex. 2013 ; Vol. 23, No. 11. pp. 2724-2733.
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