Mapping the Supratentorial Cerebral Arterial Territories Using 1160 Large Artery Infarcts

Dong Eog Kim, Jong Ho Park, Dawid Schellingerhout, Wi Sun Ryu, Su Kyoung Lee, Min Uk Jang, Sang Wuk Jeong, Jeong Yong Na, Jung E. Park, Eun Ja Lee, Ki Hyun Cho, Joon Tae Kim, Beom Joon Kim, Moon Ku Han, Jun Lee, Jae Kwan Cha, Dae Hyun Kim, Soo Joo Lee, Youngchai Ko, Byung Chul LeeKyung Ho Yu, Mi Sun Oh, Keun Sik Hong, Yong Jin Cho, Jong Moo Park, Kyusik Kang, Tai Hwan Park, Kyung Bok Lee, Kyoung Jong Park, Heung Kook Choi, Juneyoung Lee, Hee Joon Bae

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Abstract

Importance: Cerebral vascular territories are of key clinical importance in patients with stroke, but available maps are highly variable and based on prior studies with small sample sizes. Objective: To update and improve the state of knowledge on the supratentorial vascular supply to the brain by using the natural experiment of large artery infarcts and to map out the variable anatomy of the anterior, middle, and posterior cerebral artery (ACA, MCA, and PCA) territories. Design, Setting, and Participants: In this cross-sectional study, digital maps of supratentorial infarcts were generated using diffusion-weighted magnetic resonance imaging (MRI) of 1160 patients with acute (<1-week) stroke recruited (May 2011 to February 2013) consecutively from 11 Korean stroke centers. All had supratentorial infarction associated with significant stenosis or occlusion of 1 of 3 large supratentorial cerebral arteries but with patent intracranial or extracranial carotid arteries. Data were analyzed between February 2016 and August 2017. Main Outcomes and Measures: The 3 vascular territories were mapped individually by affected vessel, generating 3 data sets for which infarct frequency is defined for each voxel in the data set. By mapping these 3 vascular territories collectively, we generated data sets showing the Certainty Index (CI) to reflect the likelihood of a voxel being a member of a specific vascular territory, calculated as either ACA, MCA, or PCA infarct frequency divided by total infarct frequency in that voxel. Results: Of the 1160 patients (mean [SD] age, 67.0 [13.3] years old), 623 were men (53.7%). When the cutoff CI was set as 90%, the volume of the MCA territory (approximately 54% of the supratentorial parenchymal brain volume) was about 4-fold bigger than the volumes of the ACA and PCA territories (each approximately 13%). Quantitative studies showed that the medial frontal gyrus, superior frontal gyrus, and anterior cingulate were involved mostly in ACA infarcts, whereas the middle frontal gyrus and caudate were involved mostly by MCA infarcts. The PCA infarct territory was smaller and narrower than traditionally shown. Border-zone maps could be defined by using either relative infarct frequencies or CI differences. Conclusions and Relevance: We have generated statistically rigorous maps to delineate territorial border zones and lines. The new topographic brain atlas can be used in clinical care and in research to objectively define the supratentorial arterial territories and their borders.

Original languageEnglish
JournalJAMA Neurology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology

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    Kim, D. E., Park, J. H., Schellingerhout, D., Ryu, W. S., Lee, S. K., Jang, M. U., Jeong, S. W., Na, J. Y., Park, J. E., Lee, E. J., Cho, K. H., Kim, J. T., Kim, B. J., Han, M. K., Lee, J., Cha, J. K., Kim, D. H., Lee, S. J., Ko, Y., ... Bae, H. J. (Accepted/In press). Mapping the Supratentorial Cerebral Arterial Territories Using 1160 Large Artery Infarcts. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2018.2808