Mapping the surface charge distribution of amyloid fibril

Gyudo Lee, Wonseok Lee, Hyungbeen Lee, Sang Woo Lee, Dae Sung Yoon, Kilho Eom, Taeyun Kwon

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37 Citations (Scopus)

Abstract

It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.

Original languageEnglish
Article number043703
JournalApplied Physics Letters
Volume101
Issue number4
DOIs
Publication statusPublished - 2012 Jul 23

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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  • Cite this

    Lee, G., Lee, W., Lee, H., Woo Lee, S., Sung Yoon, D., Eom, K., & Kwon, T. (2012). Mapping the surface charge distribution of amyloid fibril. Applied Physics Letters, 101(4), [043703]. https://doi.org/10.1063/1.4739494