Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor (VEGF)

Jae Hoon Cho, Hyung Seok Kim, Chang Soo Park, Jin Kook Kim, Kwang-Yoon Jung, Bong Kyung Shin, Han Kyum Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Even though oral tongue cancer is generally diagnosed at an early stage, the prognosis is poor due to frequent recurrence. Therefore, it is important to identify factors predictive of recurrence and to treat aggressively those patients with a high probability of recurrence. The relationship between angiogenesis and recurrence in tongue cancer has been widely investigated but no consensus has been reached. Mutant-type p53 and VEGF are known to be related to angiogenesis, and maspin is a potent angiogenic inhibitor but its role in tongue cancer has scarcely been examined. We observed the expression of maspin, mutant-type p53 and VEGF by immunohistochemistry in 33 patients with stages I and II oral tongue cancer. And the relationships between maspin, mutant-type p53, VEGF expression and recurrence were analyzed. Maspin and VEGF displayed a cytoplasmic staining pattern and mutant-type p53 a nuclear pattern. None of expression of maspin, mutant-type p53, and VEGF was significantly correlated with tumor recurrence (p = 0.34, 0.56, and 0.33, respectively) and survival. Maspin expression was negatively correlated with both mutant-type p53 expression (p = 0.02), and VEGF expression (p = 0.01). There was no correlation between age, sex, clinical staging, and recurrence. In conclusion, the expression of maspin is not related to recurrence of early stage oral tongue cancer. It is inversely correlated with that of mutant-type p53 and of VEGF, suggesting that the maspin gene is a mutant-type p53 target in vivo and may contribute to regulate VEGF expression.

Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalOral Oncology
Volume43
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1

Fingerprint

Tongue Neoplasms
Mouth Neoplasms
Vascular Endothelial Growth Factor A
Recurrence
Angiogenesis Inhibitors
SERPIN-B5
Immunohistochemistry
Staining and Labeling
Survival

Keywords

  • Early oral tongue cancer
  • Maspin
  • Mutant-type p53
  • Recurrence
  • VEGF

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor (VEGF). / Cho, Jae Hoon; Kim, Hyung Seok; Park, Chang Soo; Kim, Jin Kook; Jung, Kwang-Yoon; Shin, Bong Kyung; Kim, Han Kyum.

In: Oral Oncology, Vol. 43, No. 3, 01.03.2007, p. 272-277.

Research output: Contribution to journalArticle

Cho, Jae Hoon ; Kim, Hyung Seok ; Park, Chang Soo ; Kim, Jin Kook ; Jung, Kwang-Yoon ; Shin, Bong Kyung ; Kim, Han Kyum. / Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor (VEGF). In: Oral Oncology. 2007 ; Vol. 43, No. 3. pp. 272-277.
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